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MetabolomicsTetrandrine regulates NAADP-mediated calcium signalling 1 through a novel LIMP-2-dependent, sphingosine-mediated mechanism.
Tetrandrine (Tet) is an highly potent inhibitor of Ebola virus replication by blocking NAADP51 dependent calcium release through endolysosomal two-pore channels (TPCs) and a moderately potent anti-tumor agent. Using a clickable, photoaffinity probe of Tet, we identified lysosomal integral membrane p...
2025-05-23 | MTBLS12492 | MetaboLights
TranscriptomicsModulation of calcium activated potassium channels induces cardiogenesis of pluripotent stem cells and enrichment of pacemaker- like cells
Background: Ion channels are key determinants for the function of excitable cells but little is known about their role and involvement during cardiac development. Earlier work identified Ca2+-activated potassium channels of small and intermediate conductance (SKCas) as important regulators of neural...
ORGANISM(S): Mus musculus 
2011-01-03 | E-GEOD-18660 | biostudies-arrayexpress
TranscriptomicsA calcium-induced signaling cascade leading to osteogenic differentiation of human bone marrow-derived mesenchymal stromal cells
The response of osteoprogenitors to calcium (Ca2+) is of primary interest for both normal bone homeostasis and the clinical field of bone regeneration. The latter makes use of calcium phosphate-based bone void fillers to heal bone defects, but it is currently not known how Ca2+ released from these c...
ORGANISM(S): Homo sapiens 
2018-10-06 | E-MTAB-7222 | biostudies-arrayexpress
TranscriptomicsIdentification of potassium and chloride channels in eccrine sweat glands
K and Cl channels play critical role for sweat secretion, however, individual K or Cl channels and their functions are largely unknown. By comparing expreession profilings between wild-type and Eda mutant Tabby footpads we identified 4 K and 2 Cl channels highly expressed in mouse eccrine sweat glan...
ORGANISM(S): Mus musculus 
2015-12-09 | E-GEOD-73715 | biostudies-arrayexpress
TranscriptomicsMolecular Remodeling of Ion Channels in Human Atrial and Ventricular Myocytes Associated with Ischemic Cardiomyopathy
Ischemic cardiomyopathy (ICM) leads to congestive heart failure and can cause sudden cardiac death due to arrhythmia. Existing molecular knowledge base of ICM is rudimentary because of lack of specific attribution to cell type and function. This study was designed to investigate cell-specific molecu...
ORGANISM(S): Homo sapiens 
2010-05-14 | E-GEOD-17294 | biostudies-arrayexpress
ProteomicsThe calcium-permeable channel OSCA1.3 regulates plant stomatal immunity
Perception of biotic and abiotic stresses often leads to stomatal closure in plants. Rapid influx of calcium ions (Ca2+) across the plasma membrane plays an important role in this response, but the identity of Ca2+ channels involved has remained elusive. Here, we report that the Arabidopsis thaliana...
ORGANISM(S): Arabidopsis Thaliana 
2020-09-11 | PXD020852 | panorama
TranscriptomicsIdentification of the calcium-responsive genes dependent on CrzA in the filamentous fungus Aspergillus nidulans
Microarray analysis was used to identify the calcium-responsive genes dependent on CrzA in the filamentous fungus Aspergillus nidulans. In order to identify such genes, we conducted the two types of experiment. One was a comparison between wild type with calcium treatment and wild type without cal...
ORGANISM(S): Emericella nidulans 
2008-10-02 | E-GEOD-12953 | biostudies-arrayexpress
GenomicsDifferential Expression of Calcium Channels and Signaling Pathways in Hematologic Cancers
Differential Expression of Calcium Channels and Signaling Pathways in Hematologic Cancers
PRJNA785146 | ENA
ProteomicsThe β2-subunit of voltage-gated calcium channels inhibits cardiomyocyte hypertrophy through a channel-independent mechanism.
L-type voltage-gated calcium channels (LTCCs) regulate crucial physiological processes in the heart. They are composed of the Cav1 pore-forming subunit and the accessory subunits Cav, Cav2 and Cav. Cav is a cytosolic soluble protein that regulates channel trafficking and activity, but it also exerts...
ORGANISM(S): Rattus norvegicus (Rat) Rattus 
2021-09-09 | PXD016483 | Pride
L-type voltage-gated calcium channels  cav-subunit  cardiac hypertrophy  calpain  cardiomyocytes  calpastatin 
TranscriptomicsInflammatory mediators alter astrocyte genomic profiles and G-protein receptor evoked calcium signaling
Inflammation features in diverse central nervous system disorders such as stroke, trauma, neurodegeneration, infection and autoimmunity. To better understand how inflammatory mediators may alter astrocyte functions, we examined the effects of transforming growth factor-β1 (TGF-β1), lipopolysacchar...
ORGANISM(S): Mus musculus 
2012-10-18 | E-GEOD-36089 | biostudies-arrayexpress
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