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TranscriptomicsAberrant calcium influx causes fiber type shift and mitochondrial loss in skeletal muscle
Skeletal muscle excitation-contraction (EC) coupling is independent of calcium influx. In fact alternative splicing of the voltage-gated calcium channel CaV1.1 actively suppresses calcium currents in mature muscle. Why this might be necessary is not known. However, splicing defects causing aberrant ...
ORGANISM(S): Mus musculus 
2016-04-01 | E-GEOD-67803 | biostudies-arrayexpress
GenomicsDopaminergic neurons are vulnerable to dysregulation of YEATS2-dependent calcium homeostasis
Dopaminergic neurons are vulnerable to dysregulation of YEATS2-dependent calcium homeostasis
PRJNA1314219 | ENA
UnknownComputational modeling of amylin-induced calcium dysregulation in rat ventricular cardiomyocytes.
Not available
S-EPMC5881945 | biostudies-literature
GenomicsUnraveling calcium dysregulation and autoimmunity in immune mediated rippling muscle disease
Unraveling calcium dysregulation and autoimmunity in immune mediated rippling muscle disease
PRJNA1181264 | ENA
GenomicsSorbs2 Deficiency Causes Diastolic Dysfunction Through Dysregulation of Cytoskeletal Networks and Calcium Handling
Sorbs2 Deficiency Causes Diastolic Dysfunction Through Dysregulation of Cytoskeletal Networks and Calcium Handling
PRJNA1312112 | ENA
ProteomicsDysregulation of FLVCR1-dependent mitochondrial calcium handling in neural stem cells causes congenital hydrocephalus.
Congenital hydrocephalus (CH), occurring in approximately 1/1000 live births, represents an important clinical challenge due to the limited knowledge of underlying molecular mechanisms. The discovery of novel CH-genes is thus essential to shed light on the intricate processes responsible for ventric...
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD047897 | Pride
Calcium handling Mass spectrometry Flvcr1 
GenomicsCalcium dysregulation is the critical initiator in high dose chloroquine-induced programmed cell death of Plasmodium falciparum
Calcium dysregulation is the critical initiator in high dose chloroquine-induced programmed cell death of Plasmodium falciparum
PRJNA1232628 | ENA
ProteomicsiPSC-derived neurons from GBA1-associated Parkinson's disease patients show autophagic/lysosomal dysfunction and impaired calcium homeostasis
Mutations in the acid β-glucocerebrosidase (GBA1) gene, responsible for the lysosomal storage disorder Gaucher’s disease (GD), are the strongest genetic risk factor for Parkinson’s disease (PD) known to date. To elucidate the mechanisms underlying neurodegeneration in these patients, we generate...
ORGANISM(S): Homo sapiens (Human) 
2014-06-03 | PXD000866 | Pride
Tmt Neurons Human 
UnknownCalcium dysregulation potentiates wild-type myocilin misfolding: implications for glaucoma pathogenesis.
Not available
S-EPMC10085244 | biostudies-literature
TranscriptomicsCalcium dysregulation is the critical initiator in high dose chloroquine-induced programmed cell death of Plasmodium falciparum
Understanding the mechanism of action of novel antimalarial drugs is a key goal in eradicating malaria. Previously we have explored a possible alternative cell death mechanism that is elicited by micromolar amounts of the antimalarial chloroquine (CQ) against Plasmodium falciparum. The phenotypes as...
ORGANISM(S): Plasmodium falciparum 3D7 
2025-08-19 | GSE291233 | GEO
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