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ProteomicsDysregulation of FLVCR1-dependent mitochondrial calcium handling in neural stem cells causes congenital hydrocephalus.
Congenital hydrocephalus (CH), occurring in approximately 1/1000 live births, represents an important clinical challenge due to the limited knowledge of underlying molecular mechanisms. The discovery of novel CH-genes is thus essential to shed light on the intricate processes responsible for ventric...
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD047897 | Pride
Calcium handling Mass spectrometry Flvcr1 
GenomicsSecreted-frizzled-related protein 5 modulates calcium handling in human iPSC-cardiomyocytes
Secreted-frizzled-related protein 5 modulates calcium handling in human iPSC-cardiomyocytes
PRJNA1001988 | ENA
GenomicsSorbs2 Deficiency Causes Diastolic Dysfunction Through Dysregulation of Cytoskeletal Networks and Calcium Handling
Sorbs2 Deficiency Causes Diastolic Dysfunction Through Dysregulation of Cytoskeletal Networks and Calcium Handling
PRJNA1312112 | ENA
GenomicsExcitatory dysfunction drives network and calcium handling deficits in 16p11.2 duplication schizophrenia iPSC-derived neurons
Excitatory dysfunction drives network and calcium handling deficits in 16p11.2 duplication schizophrenia iPSC-derived neurons
PRJNA889052 | ENA
ProteomicsCalcium Handling in Breast Cancer
Extracellular calcium export by the breast ductal epithelium is crucial during lactation and plays a significant role in breast cancer progression. Intraductal calcium deposition is a hallmark of aggressive premalignant lesions. This study tested the hypothesis that microbiome-derived extracellular ...
ORGANISM(S): Lactobacillus (ncbitaxon:1578) Homo Sapiens (ncbitaxon:9606) 
2025-03-11 | MSV000097290 | MassIVE
TranscriptomicsSecreted-frizzled-related protein 5 modulates calcium handling in human iPSC-cardiomyocytes
End-stage heart failure caused by myocardial injury is a leading cause of death in the developed world, with high prevalence and poor prognosis. Current therapies focus on attenuating cardiac remodeling after a cardiovascular event such as myocardial infarction or pressure overload, but no therapy i...
ORGANISM(S): Homo sapiens 
2023-08-04 | GSE240053 | GEO
TranscriptomicsSorbs2 Deficiency Causes Diastolic Dysfunction Through Dysregulation of Cytoskeletal Networks and Calcium Handling
Sorbin and SH3 domain–containing protein 2 (Sorbs2) is a cytoskeletal adaptor protein implicated in cardiomyocyte adhesion, cytoskeletal remodeling, and calcium handling. We investigated its role in diastolic dysfunction using Sorbs2 knockout (KO) mice. Sorbs2 KO mice developed progressive diastolic...
ORGANISM(S): Mus musculus 
2026-05-21 | GSE306787 | GEO
GenomicsHypoxia-responsive ZEB2 regulates a network of calcium handling genes in the injured heart
Hypoxia-responsive ZEB2 regulates a network of calcium handling genes in the injured heart
PRJNA992493 | ENA
TranscriptomicsExcitatory dysfunction drives network and calcium handling deficits in 16p11.2 duplication schizophrenia iPSC-derived neurons
Background ­- Schizophrenia (SCZ) is a debilitating psychiatric disorder with a large genetic contribution; however, its neurodevelopmental substrates remain largely unknown. Modeling pathogenic processes in SCZ using human iPSC-derived neurons (iNs) has emerged as a promising strategy. Copy number ...
ORGANISM(S): Homo sapiens 
2022-10-13 | GSE215183 | GEO
UnknownMyocardial Calcium Handling in Type 2 Diabetes: A Novel Therapeutic Target.
Not available
S-EPMC10817027 | biostudies-literature
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