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MetabolomicsGut Microbiome and Metabolome Signatures in Calcium Oxalate Stone Recurrence: A Multi-Omics Study

Background: The incidence and recurrence rate of nephrolithiasis have been increasing annually. Recent evidence highlights a close association between the composition and function of the gut microbiome and the occurrence and recurrence of kidney stones. We performed a multi-omic study to investig...

2026-03-03 | MTBLS13960 | MetaboLights
TranscriptomicsAnalysis of altered LncRNA expression profiles in proximal renal tubular cells in response to calcium oxalate monohydrate crystal adhesion
The present study aims to assess the potential changes in LncRNAs of proximal renal cells in response to the adhesion of calcium oxalate monohydrate (COM) crystals. lncRNA microarray were applied to evaluate the expression of HK-2 cells exposed to COM crystal for 0 and 24 hours.
ORGANISM(S): Homo sapiens 
2014-04-26 | E-GEOD-57111 | biostudies-arrayexpress
TranscriptomicsAnalysis of altered microRNA expression profiles in proximal renal tubular cells in response to calcium oxalate monohydrate crystal adhesion
The present study aims to assess the potential changes in microRNAs of proximal renal tubular cells in response to the adhesion of calcium oxalate monohydrate (COM) crystals. microRNA microarray was applied to evaluate the expression of HK-2 cells exposed to COM crystals for 0 and 24 hours.
ORGANISM(S): Homo sapiens 
2014-04-22 | E-GEOD-56934 | biostudies-arrayexpress
ProteomicsDegradation of calcium oxalate by Azospirillum OX-1 and its molecular mechanism
The oxalate-carbonate Pathway (OCP) refers to the biotransformation process of soil Oxalate degradation and coupled Carbonate formation. It is of great significance to explore this complex biotransformation process to improve the suitable rhizosphere environment and promote soil carbon cycle. A stra...
ORGANISM(S): Azospirillum Brasilense Sp245 
PXD041599 |
GenomicsmiRNA expression profile in calcium oxalate (CaOx) nephrocalcinosis model.
miRNA expression profile in calcium oxalate (CaOx) nephrocalcinosis model.
PRJNA776020 | ENA
ProteomicsEffects of secretome derived from macrophages exposed to calcium oxalate crystals on renal fibroblast activation
The association between kidney stone disease and renal fibrosis has been widely explored in recent years but its underlying mechanisms remain far from complete understanding. Using label-free quantitative proteomics (nanoLC-ESI-LTQ-Orbitrap MS/MS), this study identified 23 significantly altered secr...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD027039 | Pride
Calcium oxalate  kidney stone  macrophage  renal fibrosis  secretome 
ProteomicsCharacterizations of HSP90-interacting complex in renal cells using tandem affinity purification and its potential role in kidney stone formation
Heat shock protein 90 (HSP90) is a highly abundant molecular chaperone that interacts with many other intracellular proteins to regulate various cellular processes. However, compositions of the HSP90-interacting complex remain underinvestigated. This study thus aimed to characterize such complex in ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-12-17 | MSV000083252 | MassIVE
ProteomicsOxidative modifications of urinary proteins increase kidney stone risk
Clinical and animal studies have demonstrated the increasing evidence of oxidative stress in kidney stone disease. Recent findings have shown that the interactions between calcium oxalate (CaOx) crystals and renal tubular cells can promote many cellular events such as cell proliferation, cell death,...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD019360 | Pride
Calcium oxalate  kidney stone  oxidative stress  post-translation modification  uromodulin 
GenomicsEffect of calcium oxalate microcrystals on kidney proximal tubule epithelial cell gene expression in microgravity
Effect of calcium oxalate microcrystals on kidney proximal tubule epithelial cell gene expression in microgravity
PRJNA1291190 | ENA
GenomicsCalcium oxalate crystal induced transcriptomic changes in renal epithelial cells.
Small molecule inhibiton of calcium oxalate induced transcriptomic changes of renal epithelial cells.
PRJEB34728 | ENA
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