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TranscriptomicsTranscription profiling of neutrophils exposed to S. aureus infection
Neutrophil lysis after phagocytosis is a process potentially important in the pathogenesis of community-associated methicillin-resistant S. aureus (CA-MRSA) infection. The mechanism for this process is not currently known. Therefore, to better understand CA-MRSA virulence we used human oligonucleo...
ORGANISM(S): Homo sapiens 
2010-06-09 | E-GEOD-16837 | biostudies-arrayexpress
UnknownChronic hypoxia impairs skeletal muscle repair via HIF-2α stabilization.
Not available
S-EPMC10995261 | biostudies-literature
TranscriptomicsTranscription profiling of polymorphonuclear leukocyte from patients affected with autosomal dominant monocytopenia and an increased susceptibility to mycobacterial infection.
We identified 18 patients with the distinct clinical phenotype of disseminated nontuberculous mycobacterial infections, viral infections, especially with human papillomaviruses, and fungal infections, primarily histoplasmosis and molds. This syndrome typically had its onset in adulthood and was char...
ORGANISM(S): Homo sapiens 
2010-01-01 | E-GEOD-16020 | biostudies-arrayexpress
UnknownJust-in-Time Simulation Training to Augment Overnight ICU Resident Education.
Not available
S-EPMC11641875 | biostudies-literature
TranscriptomicsGene expression data from F. tularensis-exposed neutrophils
We demonstrated recently that both constitutive and FAS-triggered apoptosis of human neutrophils are profoundly impaired by Francisella tularensis, but how this is achieved is largely unknown. To test the hypothesis that changes in neutrophil gene expression contribute to this phenotype, we used h...
ORGANISM(S): Homo sapiens 
2012-10-22 | E-GEOD-37416 | biostudies-arrayexpress
TranscriptomicsGene expression of 4, 5, and 6 days differentiated Flk1+ WT ES cells, and of 6 days differentiated Flk1+ Runx1-/- and Tal-1-/- ES cells
In order to identify genes that are activated in differentiating WT ESCs, but are missing in Tal-1-/- and Runx1-/- ESCs, and which might be involved in the generation of definitive hematopoietic progenitors and their specification thereafter, we performed microarray analyses on purified Flk-1+ cells...
ORGANISM(S): Mus musculus 
2013-06-18 | E-GEOD-46970 | biostudies-arrayexpress
TranscriptomicsHead and neck paragangliomas
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-08-21 | E-GEOD-49615 | biostudies-arrayexpress
TranscriptomicsSLE serum induced transcripts regulated by IFNa2b
To explore the full extent of IFN-regulated transcriptional changes, we exposed monocytes from two healthy donors to recombinant type I IFN (IFN-M-NM-12b) in vitro. RNA was extracted at 6 hrs and the expression data was normalized to that of monocytes cultured with medium. Blood monocytes isolated f...
ORGANISM(S): Homo sapiens 
2014-06-03 | E-GEOD-46921 | biostudies-arrayexpress
TranscriptomicsTranscripts induced by recombinant IFNa in healthy blood monocytes at different time points
To explore the full extent of IFN-regulated transcriptional changes, we exposed monocytes from two healthy donors to recombinant type I IFN (IFN-M-NM-12b) in vitro. RNA was extracted at different incubation times (1, 6, 24, 48 and 72 hrs) and the expression data was normalized to that of monocytes c...
ORGANISM(S): Homo sapiens 
2014-06-03 | E-GEOD-46911 | biostudies-arrayexpress
TranscriptomicsDifferentially expressed transcripts in SLE blood monocytes
To better characterize the molecules that could potentially confer antigen presenting capacity to SLE monocytes, we assessed their gene expression profile. Blood monocytes from five healthy controls and five pediatric SLE patients were isolated using CD14+ selection. Because drugs used to treat SLE ...
ORGANISM(S): Homo sapiens 
2014-06-03 | E-GEOD-46907 | biostudies-arrayexpress
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