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MetabolomicsNuclear Magnetic Resonance-Based Blood Metabolic Profiles of Rats Exposed to Short-Term Caloric Restriction
Caloric restriction increases life-span of a number of organisms. The relationship between the increase in life-span and the extent of caloric restriction, however, varies among species. The underlying mechanisms are yet unknown, but appear to be related to changes in metabolism. In order to investi...
2014-09-05 | MTBLS114 | MetaboLights
MetabolomicsA high-fiber diet mimics aging-related signatures of caloric restriction in mammals

Caloric restriction (CR) delays aging-related hallmarks in various organisms by slowing growth and development while enhancing metabolic homeostasis. However, desirable diets that harness the metabolic benefits of CR without imposing food intake restrictions remain elusive. Here we evaluated the ...

2025-06-13 | MTBLS12479 | MetaboLights
MetabolomicsProlonged fasting times reap greater geroprotective effects when combined with caloric restriction in adult female mice
Emerging new evidence highlights the importance of prolonged daily fasting periods for the health and survival benefits of calorie restriction (CR) and time-restricted feeding (TRF) in male mice; however, little is known about the impact of these feeding regimens in females. We placed 14-month-old f...
2024-05-14 | MTBLS790 | MetaboLights
MetabolomicsThe Metabolic Benefits of Short Cycles of Very Low Caloric Intake are Dependent on Diet Composition in Middle-Aged Mice
Not available
ORGANISM(S): Mus musculus 
ST001809 | MetabolomicsWorkbench
TranscriptomicsTranscription profiling of four mouse tissues following acute caloric restriction
Multi-tissue transcriptional response following acute caloric restriction in mice.
ORGANISM(S): Mus musculus 
2007-05-17 | E-MEXP-748 | biostudies-arrayexpress
TranscriptomicsLife-long caloric restriction-associated remodeling of rat white adipose tissue
This study explored the role of the growth hormone (GH) / insulin-like growth factor 1 (IGF-1) axis on the life-long caloric restriction (CR)-associated remodeling of white adipose tissue (WAT). Adipocyte size and gene expression profiles, using high-density oligonucleotide microarrays, were analyze...
ORGANISM(S): Rattus norvegicus 
2012-09-27 | E-GEOD-30668 | biostudies-arrayexpress
TranscriptomicsExpression data of worms under different caloric restriction mimetic treatments
We used microarray analysis to further our understanding of the mode of action of the well know caloric restriction mimetic rapamycin and the compound Allantoin first studied in the context of aging in this study. His work helps build on our understanding of potential caloric restriction mimetics pr...
ORGANISM(S): Caenorhabditis elegans 
2015-12-22 | E-GEOD-64336 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of cochleae from young and middle aged mice subjected to calorie restriction to examine age-related changes and calorie restriction-induced changes in gene expression in the cochlea.
Presbycusis is characterized by an age-related progressive decline of auditory function, and arises mainly from the degeneration of hair cells or spiral ganglion (SG) cells in the cochlea. Here we show that caloric restriction suppresses apoptotic cell death in the mouse cochlea and prevents late on...
ORGANISM(S): Mus musculus 
2007-11-22 | E-GEOD-4786 | biostudies-arrayexpress
TranscriptomicsMicroarray for duodenum epithelium of C57Bl6 PPARgVillinCRE and wild type mice submitted to 2 weeks 75% caloric restriction compared to ad libitum fed controls
The experiment aims at a characterization of gene expression changes in duodenum during caloric restriction. The C57BL6 mice were restricted their food intake to 75% of their normal daily portion. The food was delivered daily around 4-6pm for 14 days. The mice were housed with free access to water. ...
ORGANISM(S): Mus musculus 
2018-07-27 | E-MTAB-6248 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse amygdala after treatment with caloric restricted feeding regimes
Moderate caloric restriction (CR) and weight loss are beneficial for the promotion of health; however, there is controversy regarding the effects of dieting regimens on behavior. In this study, we investigated two different dieting regimens: repeated fasting and refeeding (RFR) and daily feeding of ...
ORGANISM(S): Mus musculus 
2009-09-25 | E-GEOD-15860 | biostudies-arrayexpress
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