Transcription profiling of mouse amygdala after treatment with caloric restricted feeding regimes

ABSTRACT: Moderate caloric restriction (CR) and weight loss are beneficial for the promotion of health; however, there is controversy regarding the effects of dieting regimens on behavior. In this study, we investigated two different dieting regimens: repeated fasting and refeeding (RFR) and daily feeding of half the amount of food consumed by RFR mice (CR). Mice in both regimens were subjected to 20% reduction in food intake and transiently reduced their body weights during the first 12 days of the study. Open field, light-dark transition, elevated plus maze, and forced swimming tests indicated that CR, but not RFR, reduced anxiety- and depressive-like behaviors, with a peak on day 8. Using a mouse whole genome microarray, we analyzed gene expression in the prefrontal cortex, amygdala, and hypothal

ORGANISM(S): Mus musculus

SUBMITTER: Yuta Yamamoto 

PROVIDER: E-GEOD-15860 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress