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GenomicsTargeting the CALR Interactome in Myeloproliferative Neoplasms
Targeting the CALR Interactome in Myeloproliferative Neoplasms
PRJNA491714 | ENA
ProteomicsOncogenic CALR Mutant C-terminus Mediates Dual Binding to the Thrombopoietin Receptor Triggering Complex Dimerization and Activation
Calreticulin (CALR) is a master lectin chaperone that guides the proper folding of integral membrane proteins in the endoplasmic reticulum. In healthy cells, CALR transiently and non-specifically interacts with thousands of immature N-glycosylated proteins through its N-terminal glycan-binding domai...
ORGANISM(S): Homo sapiens (Human) 
2023-04-11 | PXD034131 | Pride
Hdx-ms 
GenomicsTargeting the CALR Interactome in Myeloproliferative Neoplasms
Mutations in the endoplasmic reticulum (ER) chaperone calreticulin (CALR) are common in myeloproliferative neoplasm (MPN) patients, activate the thrombopoietin receptor (MPL), and mediate constitutive JAK/STAT signaling. The mechanisms by which CALR mutations cause myeloid transformation are incompl...
ORGANISM(S): Mus musculus 
2018-09-19 | GSE120134 | GEO
GenomicsRNAseq of LSK cells from knock-in mice with Calr frameshifts
RNAseq of LSK cells from knock-in mice with Calr frameshifts
PRJNA639518 | ENA
GenomicsCALR frameshift mutations accelerate maturation of megakaryocytes in MPN patient-derived iPS cells
CALR frameshift mutations accelerate maturation of megakaryocytes in MPN patient-derived iPS cells
PRJNA756365 | ENA
TranscriptomicsGene expression profile (GEP) of CALR-overexpressingCD34+ cells
In this work, we compared gene expression profile (GEP) of CD34+ cells transduced with the retroviral vector LCALRIDN with CD34+ cells transduced with the empty vector control LXIDN and of CD34+ cells treated with CALR siRNA with control cells transfected with a Non-Targeting siRNA In order to explo...
ORGANISM(S): Homo sapiens 
2020-04-12 | GSE97807 | GEO
UnknownMice with Calr mutations homologous to human CALR mutations only exhibit mild thrombocytosis.
Not available
S-EPMC6440999 | biostudies-literature
GenomicsMus musculus strain:C57Bl/6
Expression data of Lineage- Sca1+cKit+ (LSK) cells from wild-type, Calr+/-, CALRdel52 Calr+/+, or CALRdel52 Calr+/- mice.
PRJDB8643 | ENA
UnknownTargeting the CALR interactome in myeloproliferative neoplasms.
Not available
S-EPMC6302938 | biostudies-literature
GenomicsCALR mutation-induced transcriptional changes in cord blood-derived hematopoietic stem and progenitor cells
CALR mutation-induced transcriptional changes in cord blood-derived hematopoietic stem and progenitor cells
PRJNA801866 | ENA
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