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MetabolomicsDifferential role of sphingomyelin in influenza virus, rhinovirus and SARS-CoV-2 infection of Calu-3 cells
Host cell lipids play a pivotal role in the pathogenesis of respiratory virus infection. However, a direct comparison of the lipidomic profile of influenza virus and rhinovirus infections is lacking. In this study, we first compared the lipid profile of influenza virus and rhinovirus infection in a ...
2022-11-15 | MTBLS2352 | MetaboLights
TranscriptomicsTranscriptional analysis of Calu-3 2B-4 cells stimulated with Interleukin-1a and TNFa.
Calu-3 2B-4 cells were stimulated with interleukin-1a or TNFa. Transcriptional analysis of the extracted RNA was done by microarray. Calu-3 2B-4 cells were washed with phosphate-buffered saline (PBS) and treated with either IL-1a (0.001ng/ml) or TNFa (0.05ng/ml) or mock diluted in PBS for 40 min at...
ORGANISM(S): Homo sapiens 
2014-08-31 | E-GEOD-56678 | biostudies-arrayexpress
ProteomicsAllicin inhibits SARS-CoV-2 replication and abrogates the antiviral host response in the Calu-3 proteome
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic causes a major health burden. Garlic organosulfur compounds, such as the diallyl thiosulfinate allicin exert strong antimicrobial activity against various respiratory pathogens. Here, we investigated the antiviral activity of ...
ORGANISM(S): Homo sapiens (Human) 
2021-06-30 | PXD024375 | Pride
Sars-cov-2/ allicin/ vero e6/ calu-3/ proteome 
ProteomicsMolecular characterization of Calu-3 cells from submerged to Air-liquid interface to model lung infections
Air-liquid interface (ALI) model using the immortalized Calu-3 cells has been used to model lung diseases. From submerged to ALI culture condition, Calu-3 cells polarize and change to a ciliary mucus-producing cell. Polarized Calu-3 molecular and phenotypic similarity with primary cells has been pro...
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD056869 | Pride
Calu-3 Proteomics Ali Polarization 
TranscriptomicsExpression levels in strained vs. non-strained Calu-3 lung epithelial cells
Ventilator induced lung injury can lead to serious conditions like ARDS which are associated with a high mortality (around 30%, Stapleton et al., Chest, 2005). We hypothesized that changes of expression levels of different genes would lead us to the identification of critical target genes, which mig...
ORGANISM(S): Homo sapiens 
2011-02-12 | E-GEOD-27128 | biostudies-arrayexpress
TranscriptomicsTCL001: Calu-3 cells treated with either IFN alpha or gamma
Purpose of experiment was to compare transcriptomics of Calu-3 cells treated with either INF alpha or gamma. Calu-3 cells were treated with 1000 Units/ml of INFa (Sigma I4276) or 500 Units/ml of IFN γ (Sigma I3265). Cells were collected for RNA isolation at 0, 3, 6, and 18 or 22 h post treatment. E...
ORGANISM(S): Homo sapiens 
2011-11-01 | E-GEOD-33264 | biostudies-arrayexpress
TranscriptomicsHost Regulatory Network Response in Calu-3 cell Infection with A/CA/04/2009 Influenza virus
Differential Expression was determined in Calu-3 cells between mock infected and infection with A/CA/04/2009 Influenza virus at nime time points post infection. Calu-3 cells were infected with A/CA/04/2009 Influenza virus at MOI of 3, samples were collected 0,3,7,12,18, 24, 30, 36 and 48 hpi. Expres...
ORGANISM(S): Homo sapiens 
2012-05-04 | E-GEOD-37571 | biostudies-arrayexpress
TranscriptomicsICL002: Time course of Calu-3 cells infected with Influenza A/VN/1203/04
Purpose of experiment was to perform transcriptomics on Calu- 3 cells infected with Influenza A/VN/1203/04. Calu-3 cells were infected with Influenza A/VN/1203/04, at MOI of 1.0. Cells samples were collected at 0, 3, 7, 12, 18, and 24 h post infection. Each infected sample was done in duplicate. (D...
ORGANISM(S): Homo sapiens 
2011-11-01 | E-GEOD-33142 | biostudies-arrayexpress
TranscriptomicsRNAseq of Calu-3 epithelial cells treated with Cyclosporin A
Calu-3 cells are human lung cancer cells that serve as a model of respiratory epithelial cell model. Here, Calu-3 cells are used as a cell system for Middle East respiratory syndrome coronavirus and treated with Cyclosporin A To assess the effect of Cyclosporin A on the host cells, uninfected cells ...
ORGANISM(S): Homo sapiens 
2020-08-01 | E-MTAB-8222 | biostudies-arrayexpress
TranscriptomicsSCL005: icSARS CoV Urbani or icSARS deltaORF6 infections of the 2B4 clonal derivative of Calu-3 cells - Time course
Purpose of experiment was to compare transcriptomics of 2B4 cells (clonal derivative of Calu-3 cells) infected with either icSARS CoV or the icSARS deltaORF6 mutant. Calu-3 cells were infected with either icSARS CoV or the icSARS deltaORF6 mutant at MOI of 5.0. Cells samples were collected at 0, 3,...
ORGANISM(S): Homo sapiens 
2011-11-01 | E-GEOD-33267 | biostudies-arrayexpress
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