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MetabolomicsEffects of hypoxic preconditioning on neuroblastoma tumour oxygenation and metabolic signature in a chick embryo model
Hypoxia episodes and areas in tumours have been associated with metastatic dissemination and poor prognosis. Given the link between tumour tissue oxygen levels and cellular metabolic activity, we hypothesised that the metabolic profile between metastatic and non-metastatic tumours would reveal poten...
2018-08-13 | MTBLS541 | MetaboLights
TranscriptomicsPANC-1 cell differentiation
Multiple commercial microarrays for measuring genome-wide gene expression levels are currently available, including oligonucleotide and cDNA, single- and two-channel formats. This study reports on the results of gene expression measurements generated from identical RNA preparations that were obtaine...
ORGANISM(S): Homo sapiens 
2007-05-15 | E-GEOD-7785 | biostudies-arrayexpress
UnknownA Non-Canonical Calmodulin Target Motif Comprising a Polybasic Region and Lipidated Terminal Residue Regulates Localization.
Not available
S-EPMC7216078 | biostudies-literature
UnknownIL17A critically shapes the transcriptional program of fibroblasts in pancreatic cancer and switches on their protumorigenic functions.
Not available
S-EPMC8017922 | biostudies-literature
ProteomicsGID4-dependent proteome and interactome
The CTLH complex is a multi-subunit ubiquitin ligase complex that recognizes substrates with Pro/N-degrons via substrate receptor GID4. Recently, focus has turned to the complex as a potential mediator of targeted protein degradation, but the role GID4-mediated substrate ubiquitylation and proteasom...
ORGANISM(S): Homo sapiens (Human) 
2024-05-16 | PXD038487 | Pride
Human Bioid Lc-ms/ms 
GenomicsImpact of Jmjd3 and Utx histone demethylases on Histone H3 lysine 27 trimethylation (H3K27Me3) in mature CD4 SP thymocytes
While histone H3 lysine 27 trimethylation (H3K27Me3) is associated with gene silencing, whether H3K27Me3 demethylation affects transcription and cell differentiation in vivo has remained elusive. To investigate this, we conditionally inactivated the two H3K27Me3 demethylases, Jmjd3 and Utx, in non-d...
ORGANISM(S): Mus musculus 
2015-09-02 | E-GEOD-70795 | biostudies-arrayexpress
TranscriptomicsThe effect of dietary CLA on mammary tumorigenesis
Conjugated linoleic acid (CLA), a class of fatty acids found in beef and dairy products, has been shown to inhibit tumorigenesis in a variety of cancer model systems. Based on previously well-documented anti-tumor activity of CLA in rodent models of breast cancer, a pilot study was initiated to exam...
ORGANISM(S): Mus musculus 
2008-11-18 | E-GEOD-13553 | biostudies-arrayexpress
UnknownEfficacy of atezolizumab plus bevacizumab for unresectable HCC: Systematic review and meta-analysis of real-world evidence.
Not available
S-EPMC12269603 | biostudies-literature
UnknownSecond-line treatment patterns and outcomes in advanced HCC after progression on atezolizumab/bevacizumab.
Not available
S-EPMC11773230 | biostudies-literature
UnknownInherited myeloproliferative neoplasm risk affects haematopoietic stem cells.
Not available
S-EPMC7606745 | biostudies-literature
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