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ProteomicsProteomic analysis of NK cell-derived extracellular vesicles.
Natural killer (NK) cells contribute to immunosurveillance and first-line defense in the control of tumor growth and metastasis diffusion. NKEVs are constitutively secreted, are biologically active, reflect the protein and genetic repertoire of their originating cells and exert anti-tumor activity i...
ORGANISM(S): Homo sapiens (Human) 
2020-04-03 | PXD014894 | Pride
Proteomics natural killer cells exosomes microvesicles 
ProteomicsSequence analysis of Giardia virus proteins by LC-MS/MS
Giardiasis, caused by the protozoan parasite Giardia duodenalis, is an intestinal diarrheal disease affecting almost one billion people worldwide. A small endosymbiotic dsRNA viruses, G. lamblia virus (GLV), genus Giardiavirus, family Totiviridae, might inhabit human and animal isolates of G. duoden...
ORGANISM(S): Giardia intestinalis (Giardia lamblia) 
2021-07-05 | PXD025785 | Pride
Proteomics Giardia duodenalis Giardiavirus 
ProteomicsLC-MS/MS analysis of NGF proteins purified from cerebrospinal fluid
The aim of the project is to develop and validate a new method to measure proNGF in the cerebrospinal fluid of living patients, and to use it as a biomarker of Alzheimer’s disease (AD). This method, a novel proNGF immunoassay, is based on molecular size separation by capillary electrophoresis and is...
ORGANISM(S): Homo sapiens (Human) Rattus norvegicus (Rat) 
2022-02-17 | PXD025883 | Pride
Cerebrospinal fluid Alzheimer Mass spectrometry Ngf 
UnknownGenetic recombination is directed away from functional genomic elements in mice.
Not available
S-EPMC3367396 | biostudies-literature
UnknownParathyroidectomy and survival in a cohort of Italian dialysis patients: results of a multicenter, observational, prospective study.
Not available
S-EPMC10543527 | biostudies-literature
TranscriptomicsRecombination initiation maps of individual human genomes
DNA double-strand breaks (DSBs) are introduced in meiosis to initiate recombination and to generate crossovers, the reciprocal exchanges of genetic material between parental chromosomes. Here we present the first high-resolution map of meiotic DSBs in individual human genomes. Comparing DSB maps bet...
ORGANISM(S): Homo sapiens 
2014-11-17 | E-GEOD-59836 | biostudies-arrayexpress
GenomicsSequencing-based ssDNA detection
Meiotic DNA double stranded breaks (DSBs) initiate genetic recombination in discrete areas of the genome called recombination hotspots. Although DSBs can be directly mapped using ChIP-Seq and antibody against ssDNA-associated proteins, genome-wide mapping of recombination hotspots in mammals is stil...
ORGANISM(S): Mus musculus 
2012-02-21 | E-GEOD-34592 | biostudies-arrayexpress
GenomicsSupression of genetic recombination in the pseudoautosomal region and at subtelomeres in mice with a hypomorphic spo11 allele
Homologous recombination is the key process that generates genetic diversity and drives evolution. SPO11 protein triggers recombination by introducing DNA double stranded breaks at discreet areas of the genome called recombination hotspots. The hotspot locations are largely determined by the DNA bin...
ORGANISM(S): Mus musculus 
2013-09-11 | E-GEOD-48493 | biostudies-arrayexpress
ProteomicsStructural obstruction to full DNA replication in the chromatin of terminally differentiated skeletal muscle cells
Terminal cell differentiation is often associated with permanent withdrawal from proliferation, termed the postmitotic state. Though widespread among vertebrates and determinant for their biology, the molecular underpinnings of this state are poorly understood. Postmitotic skeletal muscle myotubes c...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2025-01-13 | MSV000096839 | MassIVE
UnknownViremic long-term nonprogressive HIV-1 infection is not associated with abnormalities in known Nef functions.
Not available
S-EPMC3927655 | biostudies-literature
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