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TranscriptomicsCaMKII inhibition in smooth muscle cells controls Ang-II-induced gene transcription in the aorta
The Ca2+/calmodulin-dependent kinase II is expressed in smooth muscle and believed to mediate intracellular calcium handling and calcium-dependent gene transcription. CaMKII is activated by Angiotensin-II. The multifunctional calcium/calmodulin-dependent kinase II (CaMKII) is activated by Angiotensi...
ORGANISM(S): Mus musculus 
2015-07-01 | E-GEOD-64613 | biostudies-arrayexpress
TranscriptomicsCaM Kinase II mediates maladaptive post-infarct remodeling but not acute myocardial ischemia/reperfusion injury
Calcium/calmodulin-dependent protein kinase II (CaMKII) was suggested to mediate ischemic myocardial injury and adverse cardiac remodeling. However, the specific functions of the CaMKII isoforms and splice variants in ischemia/reperfusion (I/R) injury have not been investigated yet. Thus, we studied...
ORGANISM(S): Mus musculus 
2014-09-08 | E-GEOD-58486 | biostudies-arrayexpress
GenomicsIdentification of CaMKII-dependent H3S28p target genes
To identify direct CaMKII-dependent downstream genes of H3S28p we used chromatin-immunoprecipitation followed by massive parallel DNA sequencing (ChIPseq) analysis of isolated adult murine cardiomyocytes from CamKII WT as well as from CaMKIIγ/CaMKIIδ double knockout (DKO) . DKO and WT cells were sub...
ORGANISM(S): Mus musculus 
2019-06-13 | E-MTAB-8011 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of hippocampi from wild type and alpha-CaMKII+/- mice
Comparison of the hippocampus of alpha-CaMKII+/- mice with control
ORGANISM(S): Mus musculus 
2008-10-04 | E-MEXP-962 | biostudies-arrayexpress
TranscriptomicsGene expression microarray analysis on the dentate gyrus of alpha-CaMKII HKO mice
We previously found that mice with heterozygous knockout of the alpha-isoform of calcium/calmodulin-dependent protein kinase II (alpha-CaMKII HKO mice) show various dysregulated behaviors, including cyclic variations in locomotor activity (LA), suggesting that alpha-CaMKII HKO mice may serve as an a...
ORGANISM(S): Mus musculus 
2016-03-29 | E-GEOD-68293 | biostudies-arrayexpress
ProteomicsMLC phosphorylation by the kinase CaMKII
MLC1 is membrane protein highly expressed by brain perivascular astrocytes. Mutations in MLC1 account for megalencephalic leukoencephalopathy with subcortical cysts (MLC), an incurable leu-kodystrophy characterized by macrocephaly, brain edema and cysts, myelin vacuolation and as-trocyte swelling, t...
ORGANISM(S): Homo sapiens (Human) 
2022-10-13 | PXD030549 | Pride
Mlc megalencephalic leukoencephalopathy phosphorylation mass spectrometry 
ProteomicsBreakage of the Oligomeric CaMKII Hub by the Regulatory Segment of the Kinase
Raw data for human CAMKII. For public access with the journal publication.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000086103 | MassIVE
GenomicsSkeletal muscle from CaMKII knockout mice subjected to endurance training
Skeletal muscle from CaMKII knockout mice subjected to endurance training
PRJNA1238766 | ENA
ProteomicsStructural Analysis of Hippocampal Kinase Signal Transduction
Kinases are a major clinical target for human diseases. Identifying the proteins that interact with kinases in vivo will provide information on unreported substrates and will potentially lead to more specific methods for therapeutic kinase regulation. Here, endogenous immunoprecipitations of evolu...
ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116) 
2018-05-23 | MSV000082390 | MassIVE
ProteomicsCaMKII phosphorylates βIV-spectrin in heart
Fibrosis is a pronounced feature of heart disease and the result of dysregulated activation of resident cardiac fibroblasts (CFs). Recent work identified stress-induced degradation of the cytoskeletal protein βIV-spectrin as an important step in CF activation and cardiac fibrosis. Further, loss of β...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) Chlorocebus sabaeus 
2022-02-17 | PXD025776 | Pride
Cardiac fibroblast Fibrosis Calmodulin kinase ii Stat3 Βiv-spectrin 
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