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Using a high-end mass spectrometry, we screened phosphoproteins and phosphopeptides in four types of Alzheimer's disease (AD) mouse models and human AD postmortem brains. We identified commonly changed phosphoproteins in multiple models and also determined phosphoproteins related to initiation of Ab...
ORGANISM(S): Mus musculus (Mouse) 
2014-09-10 | PXD001292 | Pride
Candida albicans metamorphoses from benign yeast to a rigid hyphae , becoming an opportunistic pathogen in immunocompromised patients. The process by which immune cells discern fungal transformations remains elusive. Here we report that the mechanosensitive ion channel Piezo1 is indispensable for re...
ORGANISM(S): Mus musculus 
2025-05-21 | GSE293094 | GEO
Candida albicans metamorphoses from benign yeast to a rigid hyphae , becoming an opportunistic pathogen in immunocompromised patients. The process by which immune cells discern fungal transformations remains elusive. Here we report that the mechanosensitive ion channel Piezo1 is indispensable for re...
ORGANISM(S): Mus musculus 
2025-05-22 | GSE279850 | GEO
Piezo1 initiates host immune defense against pathogenic fungi through mechanosensory recognition of Candida albicans hyphae
Piezo1 initiates host immune defense against pathogenic fungi through mechanosensory recognition of Candida albicans hyphae
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