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ProteomicsPseudo-acetylation of ACTC1 K326 and K328 promotes dysinhibition of reconstituted human cardiac thin filaments
Tropomyosin (Tpm) regulates cardiac thin filament function by restricting myosin access through electrostatic interactions with actin - particularly involving residues K326 and K328 on each actin monomer. Acetylation at these lysines neutralizes charge, destabilizing Tpm’s inhibitory position and fa...
ORGANISM(S): Homo sapiens (Human) 
2026-08-31 | PXD067808 | Pride
Actin Human Acetylation 
TranscriptomicsTitered FOXO overexpression maintains cardiac proteostasis and ameliorates age-associated functional decline
Heart performance declines with age. Reduced protein quality control (PQC) due to decreased function of the ubiquitin/proteasome system (UPS), autophagy, and/or chaperone-mediated protein refolding is a likely contributor to age-associated cardiac performance decline. The transcription factor FOXO p...
ORGANISM(S): Drosophila melanogaster 
2016-07-01 | E-GEOD-73205 | biostudies-arrayexpress
ProteomicsMmulatta - Cardiac ventricle, normalized spectral counts (Kaushiketal,scitranslmed2015)
abundance based on normalized spectral counts, Interaction consistency score: 4.8, Coverage: 4
ORGANISM(S): 9544 
2015-00-00 | 1279314901 | PAXDB
ProteomicsMmulatta - Cardiac ventricle, normalized spectral counts (Kaushiketal,scitranslmed2015)
abundance based on normalized spectral counts, Interaction consistency score: 2.2, Coverage: 4
ORGANISM(S): 9544 
2015-00-00 | 14227165 | PAXDB
ProteomicsR.norvegicus - Cardiac ventricle, normalized spectral counts (Kaushiketal,scitranslmed2015)
abundance based on normalized spectral counts, Interaction consistency score: 7.5, Coverage: 4
ORGANISM(S): 10116 
2015-00-00 | 3976932592 | PAXDB
ProteomicsR.norvegicus - Cardiac ventricle, normalized spectral counts (Kaushiketal,scitranslmed2015)
abundance based on normalized spectral counts, Interaction consistency score: 6.6, Coverage: 4
ORGANISM(S): 10116 
2015-00-00 | 3650757554 | PAXDB
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