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MetabolomicsBrown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis
Brown and beige adipose tissue are emerging as distinct endocrine organs. These tissues are functionally associated with skeletal muscle, adipose tissue metabolism and systemic energy expenditure, suggesting an interorgan signaling network. Using metabolomics, we identify 3-methyl-2-oxovaleric acid,...
2022-03-03 | MTBLS2436 | MetaboLights
TranscriptomicsDiverse effects of cyclic AMP variants on osteogenic and adipogenic differentiation of human mesenchymal stromal cells
Osteogenic differentiation of human mesenchymal stromal cells (hMSCs) may potentially be used in cell-based bone tissue-engineering applications to enhance the bone-forming potential of these cells. Osteogenic differentiation and adipogenic differentiation are thought to be mutually exclusive, and a...
ORGANISM(S): Homo sapiens 
2018-08-05 | E-MTAB-7038 | biostudies-arrayexpress
MetabolomicsLandscape of gut microbiota and metabolites and their interaction in comorbid heart failure and depressive symptoms: a random forest analysis study

Depression is an individual risk factor for poor prognosis in patients with heart failure (HF). Recent studies show that gut microbiota and metabolites have critical role in comorbid HF and depressive symptoms. We recruited 95 subjects including 35 HF patients with depressive symptoms (HF-DS), 36...

2023-10-23 | MTBLS8183 | MetaboLights
TranscriptomicsThe role of the Ras- and cAMP-signaling pathways in stress response and sterol biosynthesis in Cryptococcus neoformans
The cAMP-pathway plays a central role in regulation of growth, differentiation, and virulence of human pathogenic fungi, including Cryptococcus neoformans. Three major upstream signaling regulators of the adenylyl cyclase (Cac1), Ras, Aca1 (Adenylyl cyclase-associated protein 1) and G-alpha subunit ...
ORGANISM(S): Cryptococcus neoformans var. grubii H99 
2010-05-22 | E-GEOD-17338 | biostudies-arrayexpress
UnknownCloning and characterization of a cAMP-specific phosphodiesterase (TbPDE2B) from Trypanosoma brucei.
Not available
S-EPMC123713 | biostudies-literature
TranscriptomicsThe coregulator, repressor of Estrogen Receptor Activity (REA), is a crucial regulator of the timing and magnitude of uterine decidualization.
Our findings establish a key role for the coregulator, Repressor of Estrogen receptor Activity (REA), in controlling the timing and magnitude of decidualization in human endometrial stromal cells in vitro and in the mouse uterus in vivo, and suggest that REA functions to synchronize uterine differen...
ORGANISM(S): Homo sapiens 
2013-04-04 | E-GEOD-42376 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of transgenic mice (tTA/IkappaBalpha-AA) treated with doxycycline (DOX), which represses expression of the transgenic IkappaBalpha
double transgenic mice (tTA/IkappaBalpha-AA) were treated with doxycycline (DOX), which represses expression of the transgenic IkappaBalpha. Double transgenic mice without Dox-treatment overexpress the transdominant IkappaBalpha, which represses NFkappaB activation.
ORGANISM(S): Mus musculus 
2006-05-10 | E-MEXP-358 | biostudies-arrayexpress
TranscriptomicsTime course of the mRNA expression after phage ϕYS40 infection in crp deletion mutant of Thermus thermophilus HB8.
We observed the expression profile of the total mRNA in crp (TTHA1437) deletion mutant strain of Thermus thermophilus HB8 during infection of bacteriophage ϕYS40. Keywords: time course, bacteriophage, infection, CRP, cAMP receptor protein, deletion mutant Three crp (TTHA1437) delection mutant strain...
ORGANISM(S): Thermus thermophilus HB8 
2009-11-02 | E-GEOD-16955 | biostudies-arrayexpress
TranscriptomicsA subcutaneous adipose tissue-liver axis in the control of hepatic gluconeogenesis
We performed RNA sequencing analysis of hepatic gene expression a few hours after amlexanox treatment, and identified over 1700 differentially expressed genes. Pathway analysis of these differentially regulated genes revealed that the top two most enriched pathways were the adipocytokine signaling p...
ORGANISM(S): Mus musculus 
2015-04-17 | E-GEOD-57054 | biostudies-arrayexpress
UnknownFgSnt1 of the Set3 HDAC complex plays a key role in mediating the regulation of histone acetylation by the cAMP-PKA pathway in Fusarium graminearum.
Not available
S-EPMC9728937 | biostudies-literature
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