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TranscriptomicsTranscription profiling of mouse intestinal cells expressing Lgr5 at high or low levels or with Ascl2 conditionally knocked out shows Ascl2 controls intestinal stem cell fate
The small intestinal epithelium is the most rapidly self-renewing tissue of mammals. Proliferative cells are confined to crypts, while differentiated cell types predominantly occupy the villi. We recently demonstrated the existence of a long-lived pool of cycling stem cells defined by Lgr5 expressio...
ORGANISM(S): Mus musculus 
2009-03-25 | E-GEOD-14201 | biostudies-arrayexpress
TranscriptomicsThe transcription factor cyclic AMP–responsive element–binding protein H regulates triglyceride metabolism
Here we report that the transcription factor cyclic AMP–responsive element–binding protein H (CREB-H, encoded by CREB3L3) is required for the maintenance of normal plasma triglyceride concentrations. CREB-H–deficient mice showed hypertriglyceridemia secondary to inefficient triglyceride clearance ca...
ORGANISM(S): Mus musculus 
2011-06-04 | E-GEOD-29643 | biostudies-arrayexpress
UnknownThe alphavirus nonstructural protein 2 NTPase induces a host translational shut-off through phosphorylation of eEF2 via cAMP-PKA-eEF2K signaling.
Not available
S-EPMC9997916 | biostudies-literature
MetabolomicsAMPK activation induces RALDH+ tolerogenic dendritic cells by rewiring glucose and lipid metabolism.
Dendritic cell (DC) activation and function are underpinned by profound changes in cellular metabolism. Several studies indicate that the ability of DCs to promote tolerance is dependent on catabolic metabolism. Yet the contribution of AMP-activated kinase (AMPK), a central energy sensor promoting c...
2024-08-16 | MTBLS10647 | MetaboLights
UnknownCAMP: a modular metagenomics analysis system for integrated multistep data exploration.
Not available
S-EPMC12809600 | biostudies-literature
UnknownThe thermoacidophilic methanotroph Methylacidiphilum fumariolicum SolV oxidizes subatmospheric H2 with a high-affinity, membrane-associated [NiFe] hydrogenase.
Not available
S-EPMC7174314 | biostudies-literature
ProteomicsChikungunya virus phosphoproteomics
SILAC-labeled MRC-5 cells were seeded in 75-cm2 flasks 1 day before infection with CHIKV-LS3 [1] at MOI 5. One hour post infection (h p.i.), the inoculum was removed and replaced with SILAC DMEM containing 2% dialyzed FBS, 0.280 mM arginine, 0.384 mM lysine, 0.5 mM proline, 25 mM HEPES, 2 mM L-Gluta...
ORGANISM(S): Homo sapiens (Human) 
2022-02-28 | PXD009381 | Pride
Chikungunya virus chikv phosphoproteomics 
UnknownTranscriptional regulation of apolipoprotein A-IV by the transcription factor CREBH.
Not available
S-EPMC3995463 | biostudies-literature
UnknownMitochondrial respiratory chain deficiency inhibits lysosomal hydrolysis.
Not available
S-EPMC6693470 | biostudies-literature
MetabolomicsHost autophagy mediates organ wasting and nutrient mobilization for tumor growth
During tumor growth-when nutrient and anabolic demands are high-autophagy supports tumor metabolism and growth through lysosomal organelle turnover and nutrient recycling. Ras-driven tumors additionally invoke non-autonomous autophagy in the microenvironment to support tumor growth, in part through ...
2021-09-24 | MTBLS2771 | MetaboLights
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