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TranscriptomicsIdentification and functional characterization of Rca1, a transcription factor involved in both antifungal susceptibility and host response in Candida albicans
The identification of novel transcription factors associated to antifungal response may allow the discovery of fungal specific targets for new therapeutic strategies. A collection of 241 C. albicans transcriptional regulators mutants was screened for altered susceptibility to fluconazole, caspofungi...
ORGANISM(S): Candida albicans 
2012-05-02 | E-GEOD-37682 | biostudies-arrayexpress
UnknownThe opportunistic pathogen Propionibacterium acnes: insights into typing, human disease, clonal diversification and CAMP factor evolution.
Not available
S-EPMC3772855 | biostudies-literature
MetabolomicsGNPS - Brain energy metabolism adenosine mediated cAMP signaling in astrocytes.
Whole brain mouse central carbon targeted LCMS metabolomics.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2024-04-01 | MSV000094445 | GNPS
MetabolomicsSARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals
Viruses manipulate cellular metabolism and macromolecule recycling processes like autophagy. Dysregulated metabolism might lead to excessive inflammatory and autoimmune responses as observed in severe and long COVID-19 patients. Here we show that SARS-CoV-2 modulates cellular metabolism and reduces ...
2021-06-11 | MTBLS2840 | MetaboLights
UnknownA 5-day intensive curriculum for interns utilizing simulation and active-learning techniques: addressing domains important across internal medicine practice.
Not available
S-EPMC6302521 | biostudies-literature
TranscriptomicsCalorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans
Resveratrol is a naturally occurring compound that profoundly affects energy metabolism and mitochondrial function and serves as a calorie restriction mimetic, at least in animal models of obesity. Here we treated 10 healthy, obese men with placebo and 150 mg/day resveratrol in a randomized double-b...
ORGANISM(S): Homo sapiens 
2011-11-08 | E-GEOD-32357 | biostudies-arrayexpress
TranscriptomicsOvercoming cetuximab resistance in HNSCC: The role of AURKB and DUSP proteins
Unraveling the underlying mechanisms of cetuximab resistance in head and neck squamous cell carcinoma (HNSCC) is of major importance as many tumors remain non-responsive or become resistant. Out microarray results suggest that resistant cells still exhibit RAS-MAPK pathway signaling contributing to ...
ORGANISM(S): Homo sapiens 
2014-09-18 | E-GEOD-61495 | biostudies-arrayexpress
TranscriptomicsCold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus.
Background: The prevalence of type 2 diabetes has increased dramatically in recent decades. Increasing brown adipose tissue (BAT) mass and activity has recently emerged as an interesting approach to not only increase energy expenditure, but also improve glucose homeostasis. BAT can be recruited by p...
ORGANISM(S): Homo sapiens 
2015-07-05 | E-GEOD-67297 | biostudies-arrayexpress
TranscriptomicsExpression data from yeast heterologously expressing alpha-ENaC, CFTR or Kir2.1 [CFTR]
Misfolded membrane proteins are retained in the endoplasmic reticulum (ER) and are subject to the ER associated degradation pathway, which clears the secretory pathway of potentially toxic species. While the transcriptional response to environmental stressors has been extensively studied, limited d...
ORGANISM(S): Saccharomyces cerevisiae 
2014-09-10 | E-GEOD-61244 | biostudies-arrayexpress
TranscriptomicsExpression data from yeast heterologously expressing alpha-ENaC, CFTR or Kir2.1 alpha-ENaC]
Misfolded membrane proteins are retained in the endoplasmic reticulum (ER) and are subject to the ER associated degradation pathway, which clears the secretory pathway of potentially toxic species. While the transcriptional response to environmental stressors has been extensively studied, limited d...
ORGANISM(S): Saccharomyces cerevisiae 
2014-09-10 | E-GEOD-61243 | biostudies-arrayexpress
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