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TranscriptomicsTranscription profiling of human soluble guanylate cyclase-deficient U937 cells exposed to the nitric oxide (NO) donor S-nitrosoglutathione to provide insight into the cGMP-independent effects of NO
NO effects on gene expression, independent of cGMP, were examined globally. Differentiated human U937 cells that lack soluble guanylate cyclase were exposed to Snitrosoglutathione, a NO donor, or glutathione without or with dibutyryl-cAMP (Bt2cAMP). NO regulated 110 transcripts that annotated dispro...
ORGANISM(S): Homo sapiens 
2007-09-11 | E-GEOD-2649 | biostudies-arrayexpress
TranscriptomicsThe molecular response of Clostridium thermocellum ATCC 27405 to ethanol shock
Clostridium thermocellum is a Gram-positive, anaerobic, thermophilic bacterium that ferments cellulose into ethanol. It is a candidate industrial consolidated bioprocess (CBP) biocatalyst for lignocellulosic bioethanol production. However, C. thermocellum is relatively sensitive to ethanol compared ...
ORGANISM(S): Clostridium thermocellum ATCC 27405 
2012-08-16 | E-GEOD-25236 | biostudies-arrayexpress
ProteomicsIdentification of phosphorylation sites regulated by lysophosphatidic acid (LPA) in OCMI91s ovarian cancer cells
Elevated levels of lysophosphatidic acid (LPA) species accumulate in the ascites of ovarian high grade serous cancer (HGSC) and are associated with a short relapse-free survival. LPA is known to support the metastatic spread of cancer cells by activating a multitude of signaling pathways through G-p...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-01-25 | MSV000091146 | MassIVE
ProteomicsIdentification of phosphorylation sites regulated by lysophosphatidic acid (LPA) in OVCAR8 ovarian cancer cells
Elevated levels of lysophosphatidic acid (LPA) species accumulate in the ascites of ovarian high grade serous cancer (HGSC) and are associated with a short relapse-free survival. LPA is known to support the metastatic spread of cancer cells by activating a multitude of signaling pathways through G-p...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-01-26 | MSV000091158 | MassIVE
TranscriptomicsHuman iPSC-based Modeling of Late-Onset Disease using Progerin-induced Aging
Reprogramming somatic cells to induced pluripotent stem cells (iPSCs) sets their identity back to an embryonic age. This presents a fundamental hurdle for modeling late-onset disorders using iPSC-derived cells. We therefore developed a strategy to induce age-like features in multiple iPSC-derived li...
ORGANISM(S): Homo sapiens 
2014-01-23 | E-GEOD-52431 | biostudies-arrayexpress
TranscriptomicsGene Expression in White Adipose Tissue of KSR2-/- mice compared to wild type mice
The goal of this study was to define the gene expression changes that take place in the white adipose tissue of KSR2-/- mice at 6 months of age. Three wild type mice and three KSR2-/- mice were used for total RNA extraction from white adipose tissue. The RNA from each mouse was analyzed on one Affy...
ORGANISM(S): Mus musculus 
2009-09-03 | E-GEOD-17923 | biostudies-arrayexpress
TranscriptomicsTranscriptome and translational signaling following endurance exercise in trained skeletal muscle: impact of dietary protein
Impact of protein ingestion following 1 h intense cycling on the induced transcriptome and signaling in biopsy samples from endurance-trained men, relative to isocaloric control Single blind, randomized, crossover design comprising two experimental blocks. During the blocks, exercise and diet were c...
ORGANISM(S): Homo sapiens 
2011-11-21 | E-GEOD-27285 | biostudies-arrayexpress
MetabolomicsSARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals
Viruses manipulate cellular metabolism and macromolecule recycling processes like autophagy. Dysregulated metabolism might lead to excessive inflammatory and autoimmune responses as observed in severe and long COVID-19 patients. Here we show that SARS-CoV-2 modulates cellular metabolism and reduces ...
2021-06-11 | MTBLS2840 | MetaboLights
TranscriptomicsRescue Of Dysfunctional Autophagy By Peptide IDR-1018 Attenuates Hyperinflammatory Phenotype Of Cystic Fibrosis Cells
Genome-wide gene expression was measured in two cell lines: CF bronchial epithelial cell line IB3-1 (compound heterozygote for the ΔF508 and W1282X CFTR mutations) and the isogenic, CFTR-corrected C38 cell line, after treatment with the flagellin protein FliC, and/or synthetic peptide IDR-1018. Tota...
ORGANISM(S): Homo sapiens 
2012-11-05 | E-GEOD-35391 | biostudies-arrayexpress
TranscriptomicsExpression data of MCF-7 cells treated with gamma tocotrienol (g-T3)
Gamma tocotrienol induces apoptosis in breast cancer cells however, the molecular mechanisms are not completely understood. We used microarrays to detail the global programme of gene expression underlying the effects of gamma tocotrienols on MCF-7 cells and identified distinct classes of up-regulate...
ORGANISM(S): Homo sapiens 
2011-03-31 | E-GEOD-21946 | biostudies-arrayexpress
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