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TranscriptomicsTranscription profiling of mouse S49 cells to study the global impact of cAMP and protein kinase A on gene expression
Although a substantial number of hormones and drugs increase cellular cAMP levels, the global impact of cAMP and its major effector mechanism, protein kinase A (PKA), on gene expression is not known. Here we show that treatment of wild-type S49 lymphoma cells for 24 h with 8-(4-chlorophenylthio)-cAM...
ORGANISM(S): Mus musculus 
2007-08-31 | E-GEOD-2413 | biostudies-arrayexpress
GenomicsGenomic mapping of cAMP receptor protein binding in relation to transcriptional start sites in Mycobacterium tuberculosis
In this study we have used ChIPseq analysis to perform comprehensive mapping of the binding profile of the cAMP receptor protein (CRPMt) of M. tuberculosis combined with RNAseq studies to further investigate the transcriptional response following crp gene deletion and under alternative growth condi...
ORGANISM(S): Mycobacterium tuberculosis 
2014-06-24 | E-MTAB-2390 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation of human cell lines to identify cAMP-response element binding protein (CREB) binding sites.
Hormones and nutrients often induce genetic programs via signaling pathways that interface with gene-specific activators. Activation of the cAMP pathway, for example, stimulates cellular gene expression by means of the PKA-mediated phosphorylation of cAMP-response element binding protein (CREB) at S...
ORGANISM(S): Homo sapiens 
2006-05-09 | E-WMIT-11 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse S49 lymphoma cell deathless (D-) cell variant
The second messenger cAMP acts via protein kinase A (PKA) to induce apoptosis by mechanisms that are poorly understood. Here, we assessed a role for mitochondria and analyzed gene expression in cAMP/PKA-promoted apoptosis by comparing wild-type (WT) S49 lymphoma cells and the S49 variant, D- (cAMP-d...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9727 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of overexpression of the Rv0805 phosphodiesterase elicits a cAMP-independent transcriptional response
The Rv0805 gene in Mycobacterium tuberculosis encodes a metallophosphoesterase which shows cAMP-hydrolytic activity. Overexpression of Rv0805 has been used as a tool to lower intracellular cAMP levels and thereby elucidate the roles of cAMP in mycobacteria. Here we show that levels of cAMP in M. tub...
ORGANISM(S): Mycobacterium tuberculosis 
2013-11-02 | E-BUGS-146 | biostudies-arrayexpress
ProteomicsQuantitative phosphoproteomics reveal novel roles of cAMP in plants
3′,5′-cyclic adenosine monophosphate (cAMP) is finally recognized as an essential signaling molecule in plants where cAMP-dependent processes include responses to hormones and environmental stimuli. To better understand the role of cAMP at the systems level, we have undertaken a phosphoproteomic ana...
ORGANISM(S): Nicotiana tabacum (Common tobacco) 
2024-05-24 | PXD040912 | Pride
Cyclic nucleotide Camp Cyclic adenosine monophosphate Rna splicing Kinases 
TranscriptomicsS. cerevisiae mutant with a constitutively activated Ras/cAMP pathway
Comparison of the transcriptomes of Saccharomyces cerevisiae wild type FY23 and a PDE2 deletion mutant DJ28. Keywords = PDE2 Keywords = Ras/cAMP pathway
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-05 | E-GEOD-600 | biostudies-arrayexpress
TranscriptomicsThe role of the Ras- and cAMP-signaling pathways in stress response and sterol biosynthesis in Cryptococcus neoformans
The cAMP-pathway plays a central role in regulation of growth, differentiation, and virulence of human pathogenic fungi, including Cryptococcus neoformans. Three major upstream signaling regulators of the adenylyl cyclase (Cac1), Ras, Aca1 (Adenylyl cyclase-associated protein 1) and G-alpha subunit ...
ORGANISM(S): Cryptococcus neoformans var. grubii H99 
2010-05-22 | E-GEOD-17338 | biostudies-arrayexpress
Proteomics2′ ,3′-cAMP treatment mimics abiotic stress response
For many years, 2′,3′-cyclic adenosine monophosphate (2′,3′-cAMP), a positional isomer of the second messenger 3′,5′-cAMP, has not received enough attention. Recent studies have reported that 2′,3′-cAMP exists in plants and might be involved in stress signaling because 1) its level increases upon wo...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2022-05-19 | PXD028365 | Pride
2′ Abiotic stress 3′-camp Stress granules Stress response Processing bodies 
TranscriptomicsTranscription profiling time series of the cAMP-induced decidualization of human endometrial stromal cells
Timecourse of cAMP-induced decidualization of endometrial stromal cells.

Note that files GSM5962.txt and GSM5965.txt as imported from GEO are identical.
ORGANISM(S): Homo sapiens 
2007-12-13 | E-GEOD-403 | biostudies-arrayexpress
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