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TranscriptomicsInhibitors that block initiation of wall teichoic acid biosynthesis sensitize methicillin-resistant Staphylococcus aureus to beta-lactams
Methicillin resistance in Staphylococcus aureus depends on the production of mecA, which encodes penicillin-binding protein 2A (PBP2A), an acquired peptidoglycan transpeptidase with reduced susceptibility to beta-lactam antibiotics. Here, we show that preventing the expression of wall teichoic acids...
ORGANISM(S): Staphylococcus aureus 
2010-10-19 | E-GEOD-24439 | biostudies-arrayexpress
TranscriptomicsThe homeobox transcription factor Nkx2-1 regulates microRNAs controlling downstream gene silencing in lung epithelial cells (mRNA)
Cell-specific gene expression is achieved by a combination of mechanisms including transcriptional and post-transcriptional regulation. The transcription factor Nkx2-1, essential for lung cell differentiation, mainly acts in transcriptional activation but can directly or indirectly repress gene expr...
ORGANISM(S): Mus musculus 
2015-12-22 | E-GEOD-47054 | biostudies-arrayexpress
TranscriptomicsThe homeobox transcription factor Nkx2-1 regulates microRNAs controlling downstream gene silencing in lung epithelial cells (microRNA)
Cell-specific gene expression is achieved by a combination of mechanisms including transcriptional and post-transcriptional regulation. The transcription factor Nkx2-1, essential for lung cell differentiation, mainly acts in transcriptional activation but can directly or indirectly repress gene expr...
ORGANISM(S): Mus musculus 
2015-12-22 | E-GEOD-47053 | biostudies-arrayexpress
UnknownLower, more frequent cisplatin dosing minimizes hearing loss in head and neck cancer.
Not available
S-EPMC12581672 | biostudies-literature
TranscriptomicsGenome-wide Transcriptional Responses of the Filamentous Fungus Aspergillus niger to Lignocellulose (Wheat straw) using RNA-sequencing
We have studied the physiological response of the fungus Aspergillus niger when exposed to wheat straw as a model lignocellulosic substrate. Using RNA-sequencing we showed that, 24 hours after exposure to straw, gene expression of known plant cell wall degrading enzymes represents a huge investment ...
ORGANISM(S): Aspergillus niger 
2012-08-27 | E-GEOD-33852 | biostudies-arrayexpress
UnknownRandomized phase II study of dacomitinib (PF-00299804), an irreversible pan-human epidermal growth factor receptor inhibitor, versus erlotinib in patients with advanced non-small-cell lung cancer.
Not available
S-EPMC5321098 | biostudies-literature
UnknownSeagrass wasting disease prevalence and lesion area increase with invertebrate grazing across the northeastern Pacific.
Not available
S-EPMC11754935 | biostudies-literature
UnknownDevelopment of a decision tree diagram for classifying study designs in tumour pathology research: a multidisciplinary approach.
Not available
S-EPMC12664524 | biostudies-literature
UnknownUnderstanding the use of evidence in the WHO Classification of Tumours: a protocol for an evidence gap map of the classification of tumours of the lung.
Not available
S-EPMC9558796 | biostudies-literature
UnknownNew insulin glargine 300 U/ml compared with glargine 100 U/ml in insulin-naive people with type 2 diabetes on oral glucose-lowering drugs: a randomized controlled trial (EDITION 3).
Not available
S-EPMC4409854 | biostudies-literature
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