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MetabolomicsSerum organic acid metabolites can be used as potential biomarkers to identify prostatitis, benign prostatic hyperplasia, and prostate cancer (Untargeted assay)

BACKGROUND: Noninvasive methods for the early identify diagnosis of prostatitis, benign prostatic hyperplasia (BPH), and prostate cancer (PCa) are current clinical challenges.

METHODS: The serum metabolites of 20 healthy individuals and patients with prosta...

2023-04-17 | MTBLS6039 | MetaboLights
MetabolomicsSerum organic acid metabolites can be used as potential biomarkers to identify prostatitis, benign prostatic hyperplasia, and prostate cancer (Targeted organic acid assay)

BACKGROUND: Noninvasive methods for the early identify diagnosis of prostatitis, benign prostatic hyperplasia (BPH) and prostate cancer (PCa) are current clinical challenges.

METHODS: The serum metabolites of 20 healthy individuals and patients with prostat...

2023-04-17 | MTBLS6038 | MetaboLights
MetabolomicsCatalpol: a compound from rehmannia glutinosa can improve hyperlipidemia by modulating gut microbiota and endogenous metabolic pathways

Catalpol, an iridoid glycoside derived from Rehmannia glutinosa, is widely recognized for its ability to reduce blood glucose levels. However, its potential therapeutic effects on hyperlipidemia (HL) have yet to be investigated. To identify novel lipid-lowering effects of catalpol potentially exe...

2025-10-20 | MTBLS13187 | MetaboLights
MetabolomicsUntargeted metabolomics as a hypothesis-generation tool in plant protection product discovery: Highlighting the potential of trehalose and glycerol metabolism of fungal conidiospores as novel targets

INTRODUCTION: The production of high quality and safe food represents a main priority for the agri-food sector in the effort to sustain the exponentially growing human population. Nonetheless, there are major challenges that require the discovery of new, alternative, and improved...

2020-09-08 | MTBLS1565 | MetaboLights
Metabolomics1H-NMR metabolomics identifies hypoxanthine as a novel metastasis-associated metabolite
Breast cancer is one of the leading causes of death in females, mainly because of metastasis. Oncometabolites, produced via metabolic reprogramming, can influence metastatic signaling cascades. Accordingly, and based on our previous results, we hypothesized that metabolites from highly metastatic br...
2025-09-19 | MTBLS7764 | MetaboLights
MetabolomicsMulti‐omics identify xanthine as a pro‐survival metabolite for nematodes with mitochondrial dysfunction
Aberrant mitochondrial function contributes to the pathogenesis of various metabolic and chronic disorders. Inhibition of insulin/IGF-1 signaling (IIS) represents a promising avenue for the treatment of mitochondrial diseases, although many of the molecular mechanisms underlying this beneficial effe...
2019-02-28 | MTBLS794 | MetaboLights
MetabolomicsFunctional metabolomics as a tool to analyze Mediator function and structure in plants
Mediator is a multiprotein transcriptional co-regulator complex composed of four modules; Head, Middle, Tail, and Kinase. It conveys signals from promoter-bound transcriptional regulators to RNA polymerase II and thus plays an essential role in eukaryotic gene regulation. We describe subunit localiz...
2018-01-30 | MTBLS450 | MetaboLights
Metabolomics4-Octyl itaconate as a metabolite derivative inhibits inflammation via alkylation of STING

The Krebs cycle-derived metabolite itaconate, whose production is catalyzed by immune response gene 1 (IRG1), has excellent potential to link immunity and metabolism in activated macrophages through alkylation or competitive inhibition of target proteins. In support of this, our previous study de...

2023-01-15 | MTBLS5877 | MetaboLights
MetabolomicsExamination of human osteoarchaeological remains as a feasible source of polar and apolar metabolites to study past conditions
Metabolomics is a modern tool that aids in our understanding of the molecular changes in organisms. Archaeological science is a branch of archaeology that explores different archaeological materials using modern analytical tools. Human osteoarchaeological material are a frequent finding in archaeolo...
2022-07-04 | MTBLS4437 | MetaboLights
MetabolomicsCitrate serves as a signal molecule to modulate carbon metabolism and iron homeostasis in Staphylococcus aureus

Pathogenic bacteria's metabolic adaptation for survival and proliferation within hosts is a crucial aspect of bacterial pathogenesis. Here, we demonstrate that citrate, the first intermediate of the tricarboxylic acid (TCA) cycle, plays a key role as a regulator of gene expression in Staphylococc...

2024-04-26 | MTBLS4276 | MetaboLights
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