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ProteomicsIRS1 phosphorylation underlies the non-stochastic probability of cancer cells to persist during EGFR inhibition therapy
Stochastic transition of cancer cells between drug-sensitive and drug-tolerant persister phenotypes has been proposed to play a key role in non-genetic resistance to therapy. Yet, we show here that cancer cells actually possess a highly stable inherited chance to persist (CTP) during therapy. This C...
ORGANISM(S): Homo sapiens (Human) 
2021-08-10 | PXD026857 | Pride
Irs1 Drug tolerant cells Drug resistance Cancer peristers Egfr inhibition Nsclc Cancer 
ProteomicsIRS1 phosphorylation underlies the non-stochastic probability of cancer cells to persist during EGFR inhibition therapy
Stochastic transition of cancer cells between drug-sensitive and drug-tolerant persister phenotypes has been proposed to play a key role in non-genetic resistance to therapy. Yet, we show here that cancer cells actually possess a highly stable inherited chance to persist (CTP) during therapy. This C...
ORGANISM(S): Homo sapiens (Human) 
2021-08-10 | PXD026844 | Pride
Irs1 Drug tolerant cells Drug resistance Cancer peristers Egfr inhibition Nsclc Cancer 
ProteomicsIRS1 phosphorylation underlies the non-stochastic probability of cancer cells to persist during EGFR inhibition therapy
Stochastic transition of cancer cells between drug-sensitive and drug-tolerant persister phenotypes has been proposed to play a key role in non-genetic resistance to therapy. Yet, we show here that cancer cells actually possess a highly stable inherited chance to persist (CTP) during therapy. This C...
ORGANISM(S): Homo sapiens (Human) 
2021-08-10 | PXD026824 | Pride
Irs1 Drug tolerant cells Drug resistance Cancer peristers Egfr inhibition Nsclc Cancer 
ProteomicsIRS1 phosphorylation underlies the non-stochastic probability of cancer cells to persist during EGFR inhibition therapy
Stochastic transition of cancer cells between drug-sensitive and drug-tolerant persister phenotypes has been proposed to play a key role in non-genetic resistance to therapy. Yet, we show here that cancer cells actually possess a highly stable inherited chance to persist (CTP) during therapy. This C...
ORGANISM(S): Homo sapiens (Human) 
2021-08-10 | PXD026805 | Pride
Irs1 Drug tolerant cells Drug resistance Cancer peristers Egfr inhibition Nsclc Cancer 
ProteomicsIRS1 phosphorylation underlies the non-stochastic probability of cancer cells to persist during EGFR inhibition therapy
Stochastic transition of cancer cells between drug-sensitive and drug-tolerant persister phenotypes has been proposed to play a key role in non-genetic resistance to therapy. Yet, we show here that cancer cells actually possess a highly stable inherited chance to persist (CTP) during therapy. This C...
ORGANISM(S): Homo sapiens (Human) 
2021-08-10 | PXD026842 | Pride
Irs1 Drug tolerant cells Drug resistance Cancer peristers Egfr inhibition Nsclc Cancer 
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