Sort   by:  
 Page size 
MetabolomicsCalenduloside E produced by Bifidobacterium animalis B960 increases glibenclamide efficacy and alleviates drug-induced adverse effects via the IRS1/PI3K/AKT signaling pathway in a type 2 diabetes model Calenduloside E produced by Bifidobacterium animalis B960 increases glibenclamide efficacy and alleviates drug-induced adverse effects via the IRS1/PI3K/AKT signaling pathway in cell, organ-on-a-chip, and mouse models of type 2 diabetes.

Glibenclamide (GLIB), a type 2 diabetes therapy, has long-term safety concerns. Probiotic–drug coadministration, an emerging adjunctive approach for metabolic diseases, improves therapeutic outcomes and side effects. Here, Bifidobacterium animalis B960 was selected from 71 probiotic strains by HP...

2025-07-08 | MTBLS12697 | MetaboLights
GenomicsPseudomonas sp. IRS1
Pseudomonas sp. IRS1 Genome sequencing and assembly
PRJNA887578 | ENA
TranscriptomicsTranscription profiling of mouse liver cells with liver specific deletion of Irs1 and/or Irs2 and Foxo1during fasting and feeding
The effect of liver specific deletion of the insulin receptor substrate-1 (Irs1) and/or Irs2 upon gene expression in the fasted and fed liver of mice; and the effect of liver specific Foxo1 deletion in the Irs1 and Irs2 knockout liver during fasting and feeding.
ORGANISM(S): Mus musculus 
2008-07-31 | E-MEXP-1649 | biostudies-arrayexpress
GenomicsIRS1 plays a dominant role in regulating pancreatic alpha cell function
IRS1 plays a dominant role in regulating pancreatic alpha cell function
PRJNA535507 | ENA
ProteomicsIRS1 phosphorylation determines a heritable probability of cancer cells to persist during EGFR inhibition therapy
Stochastic transition of cancer cells between drug-sensitive and drug-tolerant persister phenotypes has been proposed to play a key role in non-genetic resistance to therapy. Yet, we show here that cancer cells actually possess a highly stable inherited chance to persist (CTP) during therapy. This C...
ORGANISM(S): Homo sapiens (Human) 
2021-06-22 | PXD026834 | Pride
Irs1 Drug tolerant cells Drug resistance Egfr inhibition Nsclc Cancer Cancer persisters 
ProteomicsIRS1 phosphorylation underlies the non-stochastic probability of cancer cells to persist during EGFR inhibition therapy
Stochastic transition of cancer cells between drug-sensitive and drug-tolerant persister phenotypes has been proposed to play a key role in non-genetic resistance to therapy. Yet, we show here that cancer cells actually possess a highly stable inherited chance to persist (CTP) during therapy. This C...
ORGANISM(S): Homo sapiens (Human) 
2021-08-10 | PXD026842 | Pride
Irs1 Drug tolerant cells Drug resistance Cancer peristers Egfr inhibition Nsclc Cancer 
ProteomicsIRS1 phosphorylation underlies the non-stochastic probability of cancer cells to persist during EGFR inhibition therapy
Stochastic transition of cancer cells between drug-sensitive and drug-tolerant persister phenotypes has been proposed to play a key role in non-genetic resistance to therapy. Yet, we show here that cancer cells actually possess a highly stable inherited chance to persist (CTP) during therapy. This C...
ORGANISM(S): Homo sapiens (Human) 
2021-08-10 | PXD026857 | Pride
Irs1 Drug tolerant cells Drug resistance Cancer peristers Egfr inhibition Nsclc Cancer 
ProteomicsIRS1 phosphorylation underlies the non-stochastic probability of cancer cells to persist during EGFR inhibition therapy
Stochastic transition of cancer cells between drug-sensitive and drug-tolerant persister phenotypes has been proposed to play a key role in non-genetic resistance to therapy. Yet, we show here that cancer cells actually possess a highly stable inherited chance to persist (CTP) during therapy. This C...
ORGANISM(S): Homo sapiens (Human) 
2021-08-10 | PXD026844 | Pride
Irs1 Drug tolerant cells Drug resistance Cancer peristers Egfr inhibition Nsclc Cancer 
ProteomicsIRS1 phosphorylation underlies the non-stochastic probability of cancer cells to persist during EGFR inhibition therapy
Stochastic transition of cancer cells between drug-sensitive and drug-tolerant persister phenotypes has been proposed to play a key role in non-genetic resistance to therapy. Yet, we show here that cancer cells actually possess a highly stable inherited chance to persist (CTP) during therapy. This C...
ORGANISM(S): Homo sapiens (Human) 
2021-08-10 | PXD026805 | Pride
Irs1 Drug tolerant cells Drug resistance Cancer peristers Egfr inhibition Nsclc Cancer 
ProteomicsIRS1 phosphorylation underlies the non-stochastic probability of cancer cells to persist during EGFR inhibition therapy
Stochastic transition of cancer cells between drug-sensitive and drug-tolerant persister phenotypes has been proposed to play a key role in non-genetic resistance to therapy. Yet, we show here that cancer cells actually possess a highly stable inherited chance to persist (CTP) during therapy. This C...
ORGANISM(S): Homo sapiens (Human) 
2021-08-10 | PXD026824 | Pride
Irs1 Drug tolerant cells Drug resistance Cancer peristers Egfr inhibition Nsclc Cancer 
Sort   by:  
 Page size