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GenomicsBlockade of intrinsic PD-1 promotes survival, chemo resistance and tumor growth in human colon cancer
Blockade of intrinsic PD-1 promotes survival, chemo resistance and tumor growth in human colon cancer
PRJNA728970 | ENA
ProteomicsQualitative and quantitative proteomic analysis of cancer-PD1 interactome in osteosarcoma cells
The PD-1 immune checkpoint is the target for cancer immunotherapy, which has recently revolutionized cancer treatment approaches. Interestingly, PD-1 is not only expressed by immune cells but also by cancer cells, however contradictory reports are available regarding its significance. The role and P...
ORGANISM(S): Homo sapiens (Human) 
2025-03-06 | PXD050950 | Pride
Cancer-intrinsic pd-1 Pd-1 Interactome Osteosarcoma 
TranscriptomicsBlockade of intrinsic PD-1 promotes survival, chemo resistance and tumor growth in human colon cancer
Human colon cancer cells HT29, HCT116, LoVo robustly expressed PD-1. PD-1 signaling significantly decreased proliferation and promoted apoptosis in PD1+human colon cancer cells. The human anti-PD-1, Nivolumab (NIVO) ptomoted proliferation through pERK/pAKT signaling, reduced apoptosis and protected ...
ORGANISM(S): Homo sapiens 
2022-03-08 | GSE174252 | GEO
UnknownTumor-intrinsic CDC42BPB confers resistance to anti-PD-1 immune checkpoint blockade in breast cancer.
Not available
S-EPMC11489557 | biostudies-literature
UnknownAlternatively mechanistic insights into acetylation in p53-mediated transcriptional regulation of cancer cell-intrinsic PD-1.
Not available
S-EPMC11197762 | biostudies-literature
UnknownExpression of cancer cell-intrinsic PD-1 associates with PD-L1 and p-S6 and predicts a good prognosis in nasopharyngeal carcinoma.
Not available
S-EPMC8425204 | biostudies-literature
ProteomicsApplication of peptide barcoding to obtain high-affinity anti-PD-1 nanobodies
Cancer treatment has been revolutionized by immune checkpoint inhibitors, which regulate immune cell function by blocking the interactions between immune checkpoint molecules and their ligands. The interaction between programmed cell death-1 (PD-1) and programmed cell death-ligand 1 (PD-L1) is a tar...
ORGANISM(S): Escherichia Coli 
2024-03-21 | PXD041000 | JPOST Repository
UnknownIntrinsic and Extrinsic Transcriptional Profiles That Affect the Clinical Response to PD-1 Inhibitors in Patients with Non–Small Cell Lung Cancer
Not available
S-EPMC9818269 | biostudies-literature
GenomicsActivation and acetylation of tumor-intrinsic PD-L1 via HBXIP accelerates breast cancer growth
Activation and acetylation of tumor-intrinsic PD-L1 via HBXIP accelerates breast cancer growth
PRJNA666208 | ENA
GenomicsTrametinib sensitizes KRAS-mutant lung adenocarcinoma tumors to PD-1/PD-L1 axis blockade via Id1 downregulation
Trametinib sensitizes KRAS-mutant lung adenocarcinoma tumors to PD-1/PD-L1 axis blockade via Id1 downregulation
PRJNA989582 | ENA
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