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MetabolomicsUntargeted LC-MS metabolomic comparison of canine osteosarcoma McKinley cells vs normal PEKCC2382 osteoblast cells
Untargeted LC-MS metabolomics analysis was performed on McKinley canine osteosarcoma cells (Group A) and PEKCC2382 normal canine osteoblast cells (Group B). This study screens characteristic differential metabolites and elucidates distinct metabolic phenotype discrepancies between malignant osteosar...
2026-07-28 | MTBLS14700 | MetaboLights
MetabolomicsMethionine Intervention Induces PD-L1 Expression to Enhance the Immune Checkpoint Therapy Response in MTAP-deleted Osteosarcoma
Osteosarcoma (OS), a malignant bone tumor with limited treatment options, exhibits low sensitivity to immune checkpoint therapy (ICT). Through genomics and transcriptomics analyses, we have identified a subgroup of OS with methylthioadenosine phosphorylase (MTAP) deletion, which contributes to ICT r...
2026-06-09 | MTBLS11985 | MetaboLights
TranscriptomicsIntegrative analysis reveals relationships of genetic and epigenetic alterations in osteosarcoma [gene expression]
Osteosarcomas are the most common primary malignant tumours of bone, and almost all conventional osteosarcomas are high-grade tumours showing complex genomic aberrations. We have integrated genome-wide genetic and epigenetic profiles from the EuroBoNeT panel of 19 human osteosarcoma cell lines based...
ORGANISM(S): Homo sapiens 
2012-12-06 | E-GEOD-36001 | biostudies-arrayexpress
TranscriptomicsIntegrative analysis reveals relationships of genetic and epigenetic alterations in osteosarcoma [DNA copy number]
Osteosarcomas are the most common primary malignant tumours of bone, and almost all conventional osteosarcomas are high-grade tumours showing complex genomic aberrations. We have integrated genome-wide genetic and epigenetic profiles from the EuroBoNeT panel of 19 human osteosarcoma cell lines based...
ORGANISM(S): Homo sapiens 
2012-12-06 | E-GEOD-36003 | biostudies-arrayexpress
TranscriptomicsIntegrative analysis reveals relationships of genetic and epigenetic alterations in osteosarcoma [methylation]
Osteosarcomas are the most common primary malignant tumours of bone, and almost all conventional osteosarcomas are high-grade tumours showing complex genomic aberrations. We have integrated genome-wide genetic and epigenetic profiles from the EuroBoNeT panel of 19 human osteosarcoma cell lines based...
ORGANISM(S): Homo sapiens 
2012-12-06 | E-GEOD-36002 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of canine and human osteosarcoma
This SuperSeries is composed of the following subset Series: GSE16087: Gene expression profiles of canine osteosarcoma GSE16088: Gene expression profiles of human osteosarcoma GSE16091: Gene expression profiles of human osteosarcoma, set2 Pulmonary metastasis continues to be the most common cause o...
ORGANISM(S): Homo sapiens 
2009-11-03 | E-GEOD-16102 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of human osteosarcoma
Pulmonary metastasis continues to be the most common cause of death in osteosarcoma. Indeed, the 5-year survival for newly diagnosed osteosarcoma patients has not significantly changed in over 20 years. Further understanding of the mechanisms of metastasis and resistance for this aggressive pediatr...
ORGANISM(S): Homo sapiens 
2009-11-04 | E-GEOD-16088 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of human osteosarcoma, set2
Pulmonary metastasis continues to be the most common cause of death in osteosarcoma. Indeed, the 5-year survival for newly diagnosed osteosarcoma patients has not significantly changed in over 20 years. Further understanding of the mechanisms of metastasis and resistance for this aggressive pediatr...
ORGANISM(S): Homo sapiens 
2009-11-04 | E-GEOD-16091 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of canine osteosarcoma
Pulmonary metastasis continues to be the most common cause of death in osteosarcoma. Indeed, the 5-year survival for newly diagnosed osteosarcoma patients has not significantly changed in over 20 years. Further understanding of the mechanisms of metastasis and resistance for this aggressive pediatr...
ORGANISM(S): Canis lupus familiaris 
2010-05-08 | E-GEOD-16087 | biostudies-arrayexpress
TranscriptomicsMicroRNA profiling by array of human osteosarcoma and their normal bone counterpart
Profiling array: in order to investigate the microRNAs differentially expressed between osteosarcoma and their normal bone counterpart. Specimens were kept at 4 C in RNAlater for up to 1 week, then stored at 80 C. When formal pathologic interpretation of histology from other portions of the biopsy s...
ORGANISM(S): Homo sapiens 
2012-05-21 | E-MTAB-1136 | biostudies-arrayexpress
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