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Metabolomics1H NMR based urinary metabolites profiling dataset of canine mammary tumors

The identification of efficient and sensitive biomarkers for non-invasive tests is one of the major challenges in cancer diagnosis. To address this challenge, metabolomics is widely applied for identifying biomarkers that detects abnormal changes in cancer patients. Canine mammary tumors exhibit ...

2022-02-24 | MTBLS2550 | MetaboLights
TranscriptomicsMetastatic Canine Mammary Carcinomas
[original title] Metastatic Canine Mammary Carcinomas can be Identified by a Gene Expression Profile that partly Overlaps with Human Breast Cancer Profiles. Introduction: Similar to human breast cancer mammary tumors of the female dog are commonly associated with a fatal outcome due to the develop...
ORGANISM(S): Canis lupus familiaris 
2010-12-01 | E-GEOD-20718 | biostudies-arrayexpress
TranscriptomicsMetastatic Cascade is Reflected in the Gene Expression of Metastatic Canine Mammary Carcinomas Similar to Human Breast Cancer
Proliferation, dedifferentiation, loss of cell-cell contacts and angiogenesis are among the first steps of the metastasis cascade. The complex molecular pathways associated with these events in canine mammary tumors are mostly unknown and the value of this spontaneous canine tumor as a comparative m...
ORGANISM(S): Canis lupus familiaris 
2010-12-01 | E-GEOD-22516 | biostudies-arrayexpress
TranscriptomicsIdentification of Six Potential Markers for the Detection of Circulating Canine Mammary Tumor Cells in the Peripheral Blood
Circulating tumor cells in the peripheral have proven to be independent prognostic factors for overall survival the monitoring of therapeutic success of human breast cancer patients. Postmortem morphologic evidence also points towards the presence of circulating tumor cells in the peripheral blood o...
ORGANISM(S): Canis lupus familiaris 
2011-12-10 | E-GEOD-25586 | biostudies-arrayexpress
TranscriptomicsCopy Number Abnormalities in Canine Mammary Cancers
Spontaneously occurring canine mammary cancer (MC) represents an excellent model of human breast cancer, but is greatly understudied. We performed high density arrays on 12 canine MC cases, including 7 simple carcinomas and four complex carcinomas. Simple carcinomas, which histologically match human...
ORGANISM(S): Canis lupus familiaris 
2014-09-07 | E-GEOD-54535 | biostudies-arrayexpress
TranscriptomicsGene expression of canine mammary cancer stem-like cells co-cultured with tumor associated macrophages
The aim of our study was to evaluate gene expression of canine mammary cancer stem-like cells co-cultured with tumor associated macrophages. Two canine mammary cancer cell lines (CMT-U27 and P114) were stained using anti-Sca1 (stem cell antigen 1), anti-EpCAM (Epithelial cell adhesion molecule) an...
ORGANISM(S): Canis lupus familiaris 
2016-06-01 | E-GEOD-73230 | biostudies-arrayexpress
ProteomicsProteomic profiling of stromal reprogramming in canine simple mammary carcinomas using laser-capture microdissected FFPE tissue
Cancer-associated stroma (CAS) profoundly influences development and progression of tumours including mammary carcinoma (mCA). Spontaneous canine simple mCA represent relevant models of human mCA, notably also with respect to CAS reprogramming. While transcriptomic changes in CAS of mCA are well des...
ORGANISM(S): Canis familiaris (Dog) (Canis lupus familiaris) 
2021-03-30 | PXD023023 | Pride
Breast cancer Canine breast cancer Cancer-associated fibroblasts Comparative oncology Tumour stroma Cancer-associated stroma Tumour microenvironment 
UnknownCommon plasma protein marker LCAT in aggressive human breast cancer and canine mammary tumor.
Not available
S-EPMC7781914 | biostudies-literature
TranscriptomicsGene expression profiling of human and dog breast cancers
Spontaneous tumors in dog have been demonstrated to share many features with their human counterparts, including relevant molecular targets, histological appearance, genetics, biological behavior and response to conventional treatments. Mammary tumors in dog therefore provide an attractive alternati...
ORGANISM(S): Canis lupus familiaris 
2010-06-25 | E-GEOD-14999 | biostudies-arrayexpress
GenomicsMolecular homology and difference between spontaneous canine mammary cancer and human breast cancer.
Spontaneously occurring canine mammary cancer represents an excellent model of human breast cancer, but is greatly understudied. To better use this valuable resource, we performed whole-genome sequencing, whole-exome sequencing, RNA-seq, and/or high-density arrays on twelve canine mammary cancer cas...
ORGANISM(S): Canis lupus familiaris 
2014-09-07 | GSE54535 | GEO
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