Copy Number Abnormalities in Canine Mammary Cancers

ABSTRACT: Spontaneously occurring canine mammary cancer (MC) represents an excellent model of human breast cancer, but is greatly understudied. We performed high density arrays on 12 canine MC cases, including 7 simple carcinomas and four complex carcinomas. Simple carcinomas, which histologically match human breast carcinomas, harbor extensive genomic aberrations, many faithfully recapitulating key features of human breast cancer. Complex carcinomas, with luminal and myoepithelial cells both proliferating (which is rare in human breast cancer), appear to lack genomic abnormalities. Comparison of CNAs from canine mammary simple carcinomas and complex carcinomas

ORGANISM(S): Canis lupus familiaris

SUBMITTER: Deli Liu 

PROVIDER: E-GEOD-54535 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress