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UnknownMacrocyclization as a Source of Desired Polypharmacology. Discovery of Triple PI3K/mTOR/PIM Inhibitors.
The PI3K/AKT/mTOR and PIM kinase pathways contribute to the development of several hallmarks of cancer. Cotargeting of these pathways has exhibited promising synergistic therapeutic effects in liquid and solid tumor types. To identify molecules with combined activities, we cross-screened our collect...
S-EPMC8591745 | biostudies-literature
UnknownRemarkable Diversity and Prevalence of Dagger Nematodes of the Genus Xiphinema Cobb, 1913 (Nematoda: Longidoridae) in Olives Revealed by Integrative Approaches.
The genus Xiphinema includes a remarkable group of invertebrates of the phylum Nematoda comprising ectoparasitic animals of many wild and cultivated plants. Damage is caused by direct feeding on root cells and by vectoring nepoviruses that cause diseases on several crops. Precise identification of X...
S-EPMC5102458 | biostudies-literature
UnknownDivergent trends in functional and phylogenetic structure in reptile communities across Africa.
Despite extensive research on ecological community compositions, general patterns across large-scale environmental gradients have remained unclear. A widely used explanatory model is the stress dominance hypothesis (SDH), predicting that the relative influence of environmental filtering is greater i...
S-EPMC6224532 | biostudies-literature
UnknownFat accretion measurements strengthen the relationship between feed conversion efficiency and Nitrogen isotopic discrimination while rumen microbial genes contribute little.
The use of biomarkers for feed conversion efficiency (FCE), such as Nitrogen isotopic discrimination (Δ15N), facilitates easier measurement and may be useful in breeding strategies. However, we need to better understand the relationship between FCE and Δ15N, particularly the ef...
S-EPMC5832862 | biostudies-literature
UnknownThe extent of nitrogen isotopic fractionation in rumen bacteria is associated with changes in rumen nitrogen metabolism.
Nitrogen use efficiency is an important index in ruminants and can be indirectly evaluated through the N isotopic discrimination between the animal and its diet (Δ15Nanimal-diet). The concentration and source of N may determine both the extent of the N isotopic discrimination in bacteria and N use e...
S-EPMC10499230 | biostudies-literature
UnknownPartial paternal uniparental disomy (UPD) of chromosome 1 in a patient with Stargardt disease.

Purpose

Stargardt disease (STGD) is the most common juvenile macular dystrophy, characterized by central visual impairment. All recessively inherited cases are thought to be due to mutations in the ABCA4 gene, mapped to 1p21-p13.

Methods

To describe a form of non-mendelian inheritance...
S-EPMC2553007 | biostudies-literature
UnknownUntargeted metabolomics confirms the association between plasma branched chain amino acids and residual feed intake in beef heifers.
This study explored plasma biomarkers and metabolic pathways underlying feed efficiency measured as residual feed intake (RFI) in Charolais heifers. A total of 48 RFI extreme individuals (High-RFI, n = 24; Low-RFI, n = 24) were selected from a population of 142 heifers for classical plasma metabolit...
S-EPMC9707789 | biostudies-literature
ProteomicsDetection of known and novel small proteins in Pseudomonas stutzeri using a combination of bottom-up and top-down proteomics and proteogenomics
Here we performed a comprehensive genomic and proteomics analysis of P. stutzeri in aerobic and oxygen-limiting conditions. We combined de novo genome assembly relying on 3rd generation long read sequencing technologies to report the first complete P. stutzeri ATCC14405 genome, which added over 110 ...
ORGANISM(S): Pseudomonas stutzeri ATCC 14405 = CCUG 16156 
2023-08-04 | PXD037914 | Pride
Pseudomonas Metabolism Small proteome Genome annotation Direct sequencing Top-down proteomics Proteogenomics Novel small proteins Oxygen limitation 
UnknownConserving evolutionary history does not result in greater diversity over geological time scales.
Alternative prioritization strategies have been proposed to safeguard biodiversity over macroevolutionary time scales. The first prioritizes the most distantly related species-maximizing phylogenetic diversity (PD)-in the hopes of capturing at least some lineages that will successfully diversify int...
S-EPMC6571466 | biostudies-literature
UnknownInstrumented Assessment of Gait in Pediatric Cancer Survivors: Identifying Functional Impairments After Oncological Treatment-A Pilot Study.
Background/Objectives: Pediatric cancer survivors frequently experience neuromuscular sequelae related to chemotherapy-induced neurotoxicity. Agents such as vincristine, methotrexate, and platinum compounds can lead to persistent gait alterations and sensorimotor deficits that impair mobility...
S-EPMC12840154 | biostudies-literature
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