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TranscriptomicsTranscription profiling of rat REF52 cells expressing SV40 T antigens
SV40 transforms cells through the action of two oncoproteins, large T antigen and small t antigen. Small t antigen targets phosphatase PP2A, while large T antigen stimulates cell proliferation and survival by action on multiple proteins, including the tumor suppressors Rb and p53. Large T antigen al...
ORGANISM(S): Rattus norvegicus 
2009-09-12 | E-GEOD-7836 | biostudies-arrayexpress
TranscriptomicsGlobal analysis of gene expression by SV40 T antigen in mouse embryo fibroblasts
SV40 large T antigen (TAg) contributes to cell transformation, in part, by targeting two well characterized tumor suppressors, pRb and p53. TAg expression affects the transcriptional circuits controlled by Rb and by p53. We have performed a microarray analysis to examine the global change in gene ex...
ORGANISM(S): Mus musculus 
2010-08-31 | E-GEOD-20620 | biostudies-arrayexpress
TranscriptomicsA retinoblastoma allele that is mutated at its common E2F interaction site inhibits cell proliferation in gene targeted mice
The retinoblastoma protein (pRB) is best known for regulating cell proliferation through E2F transcription factors. In this report we investigate the properties of a targeted mutation that disrupts pRB interactions with the transactivation domain of E2Fs. Mice that carry this mutation endogenously (...
ORGANISM(S): Mus musculus 
2014-04-14 | E-GEOD-54924 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse small intestine epithelium exposed to SV40 T antigene
SV40 large T antigen (TAg) contributes to cell transformation, in part, by targeting two well characterized tumor suppressors, pRb and p53. TAg expression affects the transcriptional circuits controlled by Rb and by p53. We have performed a microarray analysis to examine the global change in gene ex...
ORGANISM(S): Mus musculus 
2009-09-12 | E-GEOD-16389 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse small intestines
Rb and E2F are thought to play antagonistic roles in celll proliferation. However, this model is based mostly from in vitro cell culture systems. We used small intestines to test this model in vivo. We found that deletion of E2f1-3 in the small intestine of mice suppressed the ectopic expression o...
ORGANISM(S): Mus musculus 
2010-01-19 | E-GEOD-16454 | biostudies-arrayexpress
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