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TranscriptomicsStable inhibitory activity of regulatory T cells requires the transcription factor Helios
The maintenance of immune homeostasis requires regulatory T cells (Tregs). Given their intrinsic self-reactivity, Tregs must stably maintain a suppressive phenotype to avoid autoimmunity. We report that impaired expression of the transcription factor (TF) Helios by FoxP3+ CD4 and Qa-1-restricted CD8...
ORGANISM(S): Mus musculus 
2015-09-15 | E-GEOD-73015 | biostudies-arrayexpress
TranscriptomicsImmunotherapy Targets in Tumors
Recent work has shown that cytotoxic T cells play a central role in immune-mediated control of cancers1-3, and monoclonal antibodies that target inhibitory receptors on T cells can induce significant clinical benefit in patients despite advanced disease4-6. However, many of the regulatory pathways t...
ORGANISM(S): Mus musculus 
2014-03-14 | E-GEOD-53388 | biostudies-arrayexpress
TranscriptomicsExpression analysis of zebrafish TIF1g-deficient, cdc73 deficient and double-deficient embryos
Investigation of whole genome gene expression level changes in zebrafish TIF1g-deficient, cdc73 deficient and double-deficient embryos, compared to the wild-type ebryos. A twelve-chip study using total RNA isolated from gata1-GFP positive cells (sorted by FACS) from 12 somite-stage wild type embryos...
ORGANISM(S): Danio rerio 
2010-07-13 | E-GEOD-20432 | biostudies-arrayexpress
UnknownPan-ancestry exome-wide association analyses of COVID-19 outcomes in 586,157 individuals.
Not available
S-EPMC8173480 | biostudies-literature
UnknownWhole-genome sequencing reveals host factors underlying critical COVID-19.
Not available
S-EPMC9259496 | biostudies-literature
UnknownAn international genome-wide meta-analysis of primary biliary cholangitis: Novel risk loci and candidate drugs.
Not available
S-EPMC8811537 | biostudies-literature
UnknownIdentification of common variants associated with human hippocampal and intracranial volumes.
Not available
S-EPMC3635491 | biostudies-literature
UnknownMapping the human genetic architecture of COVID-19.
Not available
S-EPMC8674144 | biostudies-literature
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