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MetabolomicsMethionine Intervention Induces PD-L1 Expression to Enhance the Immune Checkpoint Therapy Response in MTAP-deleted Osteosarcoma
Osteosarcoma (OS), a malignant bone tumor with limited treatment options, exhibits low sensitivity to immune checkpoint therapy (ICT). Through genomics and transcriptomics analyses, we have identified a subgroup of OS with methylthioadenosine phosphorylase (MTAP) deletion, which contributes to ICT r...
2026-06-09 | MTBLS11985 | MetaboLights
MetabolomicsNatural polymorphism of ZmICE1 contributes to amino acid metabolism that impacts cold tolerance in maize

Cold stress negatively affects maize (Zea mays L.) growth, development and yield. Metabolic adjustments contribute to the adaptation of maize under cold stress. We show here that the transcription factor INDUCER OF CBF EXPRESSION 1 (ZmICE1) plays a prominent role in reprogramming amino a...

2022-10-31 | MTBLS4404 | MetaboLights
TranscriptomicsMitochondrial functional aberrations in a mouse model of non-ischemic heart failure
We characterized the metabolic and cardiac mitochondrial function in a mouse model of non-ischemic HF. Inhibition of nitric oxide synthesis and hypertension, which often present together, are two important risk factors in human non-ischemic HF. Compared with L-NAME L-NG-Nitroarginine methyl ester (L...
ORGANISM(S): Mus musculus 
2016-01-19 | E-GEOD-72132 | biostudies-arrayexpress
TranscriptomicsTemporal Control of Macrophage Pro-inflammatory Phenotype by a Biphasic HIF-1α Regulatory Program
Hypoxia-inducible factor 1α (HIF-1α) broadly orchestrates metabolic reprogramming in inflammatory macrophages. However, how HIF-1α is activated in the earliest events following pattern recognition receptor activation remains unclear. We found that HIF-1α is functionally active shortly after macroph...
ORGANISM(S): Mus musculus 
2026-07-13 | E-MTAB-16172 | biostudies-arrayexpress
UnknownSynchronous Healing of Li Metal Anode via Asymmetrical Bidirectional Current.
Not available
S-EPMC6957000 | biostudies-literature
UnknownLong-Term Stabilization/Solidification of Arsenic-Contaminated Sludge by a Blast Furnace Slag-Based Cementitious Material: Functions of CaO and NaCl.
Not available
S-EPMC9475631 | biostudies-literature
UnknownReaction temperature sensing (RTS)-based control for Li-ion battery safety.
Not available
S-EPMC4675999 | biostudies-literature
UnknownPromoting cationic redox and stabilizing lattice oxygen in an Fe-based DRX cathode by the synergy of initial Li deficiency and 3D hierarchical porous architecture.
Not available
S-EPMC12278834 | biostudies-literature
MetabolomicsMetabolite signatures of diverse Camellia sinensis tea populations
Tea plants (Camellia sinensis) present an excellent system to study evolution and diversification of specialized metabolites due to their abundance in classes, numbers and contents. A large number of tea cultivars have been cultivated throughout the world not only because of their adaption to differ...
2020-10-05 | MTBLS1405 | MetaboLights
UnknownMan or machine? Prospective comparison of the version 2018 EASL, LI-RADS criteria and a radiomics model to diagnose hepatocellular carcinoma.
Not available
S-EPMC6896342 | biostudies-literature
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