Sort   by:  
 Page size 
ProteomicsMi-2β promotes immune evasion in melanoma by activating EZH2 methylation
For identification of Mi-2β-interacting proteins, B16F10 cells (1 × 108) were collected and washed three times with PBS and lysed in lysis buffer on ice for 30 min. Cell lysates were collected and then isolated over night by anti-Mi-2β magnetic agarose beads. The anti-Mi-2β magnetic agarose beads we...
ORGANISM(S): Mus Musculus 
2024-02-18 | PXD049467 |
TranscriptomicsRNA-seq of cardiac-specific Cdk1 knockout mice at 3 weeks after experimental myocardial infarction
Biological Relevance and Intent of the Experiment: The objective of this study is to elucidate the role of Cdk1 in cardiac function, specifically its contribution to cardiomyocyte proliferation and response to injury. Using a heart-specific Cdk1 knockout mouse model, we investigate the molecular and...
ORGANISM(S): Mus musculus domesticus 
2024-12-02 | E-MTAB-14508 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA sequencing of bone marrow cells and spleen isolated from mice after sham surgery or myocardial infarction, followed by treatments (vehicle/4-oxo-RA)
Study of the impact of 4-oxo-RA on LSK (bone marrow and spleen) cell characteristics post-myocardial infarction in C57BL/6J mice. Myocardial infarction was induced in female C57BL/6J mice (aged 6 to approximately 12 weeks) through LAD occlusion. Post-surgery, mice were intraperitoneally injected wit...
ORGANISM(S): Mus musculus 
2025-02-06 | E-MTAB-13510 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA sequencing of bone marrow cells isolated from RarB KO mice after sham surgery or myocardial infarction, followed by treatments (vehicle/4-oxo-RA)
Study of the impact of 4-oxo-RA on LSK cell characteristics post-myocardial infarction in RarB KO mice. Myocardial infarction was induced in female RarB KO mice aged 6 to 12 weeks by LAD occlusion. On the 1st and 2nd post-MI days, mice were intraperitoneally injected with 30 mg/kg 4-oxo-RA (MI+4-oxo...
ORGANISM(S): Mus musculus 
2025-02-06 | E-MTAB-13511 | biostudies-arrayexpress
TranscriptomicsRNA-seq of cardiac-specific Cdk1 knockout mice at 4 days after experimental myocardial infarction
Biological Relevance and Intent of the Experiment: The objective of this study is to elucidate the role of Cdk1 in cardiac function, specifically its contribution to cardiomyocyte (CM) proliferation and response to injury. Using a heart-specific Cdk1 knockout mouse model, we investigate the molecula...
ORGANISM(S): Mus musculus domesticus 
2024-10-31 | E-MTAB-14505 | biostudies-arrayexpress
TranscriptomicsExpression data from C57BL/6J and MRL/MpJ hearts following acute myocardial infarction
The Murphy Roth Large (MRL) mouse, a strain capable of regenerating right ventricular myocardium, has a high post-myocardial infarction (MI) survival rate compared with C57BL6/J (C57) mice. The biological processes responsible for this survival advantage are unknown. We compared acute post-MI gene e...
ORGANISM(S): Mus musculus 
2010-05-27 | E-GEOD-19322 | biostudies-arrayexpress
MetabolomicsGlycaemic variability identified as a critical determinant of myocyte dysfunction and risk for myocardial injury in preclinical models of diabetes
Heart disease is the leading cause of morbidity and mortality in individuals with diabetes, due largely to risks associated with ischaemic injuries such as myocardial infarction (MI). We use human population genetic data to demonstrate that current biomarkers of hyperglycaemia do not account for ris...
2026-02-06 | MTBLS11411 | MetaboLights
UnknownMi-2β promotes immune evasion in melanoma by activating EZH2 methylation.
Not available
S-EPMC10924921 | biostudies-literature
UnknownMI-773, a breaker of the MDM2/p53 axis, exhibits anticancer effects in neuroblastoma via downregulation of INSM1.
Not available
S-EPMC8548782 | biostudies-literature
TranscriptomicsSingle-cell RNA sequencing of mouse myeloid cardiac tdTomato+ and tdTomato- cells (Fgd5-CreERT2) post-myocardial infarction upon DMSO and 4-oxo-RA treatment.
This lineage tracing experiment focused on studying the transcriptome of cardiac myeloid cells derived from BM HSCs post-MI. We performed Left coronary artery ligation (LAD) in a tamoxifen-inducible in vivo HSC-lineage tracing mouse model which allows HSC-progeny lineage tracing via Tomato expressio...
ORGANISM(S): Mus musculus 
2025-02-06 | E-MTAB-13580 | biostudies-arrayexpress
Sort   by:  
 Page size