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TranscriptomicsUnderstanding Vitamin D resistance using array comparative genomic hybridization
Vitamin D is the strongest known natural anti-proliferative. A large number of studies in a wide spectrum of cancers, including epidemiological, in vitro and animal models, demonstrate that the active form of Vitamin D has anti-cancer benefits, affecting both progression and metastasis. Alike the ro...
ORGANISM(S): Homo sapiens 
2008-05-31 | E-GEOD-9887 | biostudies-arrayexpress
TranscriptomicsSpironolactone effect on renal RNA expression in 36 wk old NZB/W F1 female mice
The purpose of this study was to examine the effect of aldosterone receptor blockade on the immunopathogenesis and progression of nephritis in the (NZBxNZW) F1 murine lupus model. Female NZB/W F1 mice (11 weeks old) were treated daily with 25 or 50 mg/kg of oral spironolactone or vehicle. Proteinuri...
ORGANISM(S): Mus musculus 
2010-05-26 | E-GEOD-10144 | biostudies-arrayexpress
UnknownA human cell atlas of fetal gene expression.
Not available
S-EPMC7780123 | biostudies-literature
TranscriptomicsSilencing factors induce the elimination of nucleosome-free regions in S. pombe heterochromatin
Abstract: In the yeast S. pombe, multiple chromatin-modifying enzymes are required for heterochromatin formation, yet how their actions alter chromatin structure to block access to DNAby the transcriptional machinery is unknown. We constructed high-resolution nucleosome occupancy maps of heterochrom...
ORGANISM(S): Schizosaccharomyces pombe 
2010-11-24 | E-GEOD-19596 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNAseq of Human T lymphocyte derived from H7N9 infected patients
Comparing transcriptomes of CD8 T cells derived from a fatal H7N9 influenza infection with those derived from a patient that survived the infection. Specifically, CD38+ HLA-DR+ cells were sorted by flow cytometry at different sampling time-points, and the transcriptome was analysed using Smart-seq2.
ORGANISM(S): Homo sapiens 
2018-01-30 | E-MTAB-6379 | biostudies-arrayexpress
TranscriptomicsComparison of lymph node negative (N0) and lymph node metastasis (N+) head and neck squamous-cell carcinomas (HNSCC)
A classifier was build on 82 training samples to differentiate between lymph node negative (N0) and lymph node metastasis (N+) head and neck squamous-cell carcinomas (HNSCC). The 102 predictor genes that resulted from this classifier where then validated against a independent validation set.
ORGANISM(S): Homo sapiens 
2005-01-09 | E-UMCU-11 | biostudies-arrayexpress
TranscriptomicsMolecular Adaptations of Striatal Spiny Projection Neurons During Levodopa-Induced Dyskinesia
L-3,4-dihydroxyphenylalanine (levodopa) treatment is the major pharmacotherapy for Parkinson's disease. However, almost all patients receiving levodopa eventually develop debilitating involuntary movements (dyskinesia). While it is known that striatal spiny projection neurons (SPNs) are involved in ...
ORGANISM(S): Mus musculus 
2014-03-03 | E-GEOD-55096 | biostudies-arrayexpress
UnknownCommunity-wide hackathons to identify central themes in single-cell multi-omics.
Not available
S-EPMC8340473 | biostudies-literature
TranscriptomicsSuppression and Activation of the Malignant Phenotype by Extracellular Matrix in Xenograft Models of Bladder Cancer: A Model for Tumor Cell Dormancy
A major problem in cancer research is the lack of a tractable model for delayed metastasis. Herein we show that cancer cells suppressed by SISgel, a gel-forming normal ECM material derived from Small Intestine Submucosa, in flank xenografts show properties of suppression and re-activation that are v...
ORGANISM(S): Homo sapiens 
2014-02-20 | E-GEOD-35947 | biostudies-arrayexpress
GenomicsGenome wide profiling of MBD2 binding
We show that in vivo MBD2 is mainly recruited to CpG island promoters that are highly methylated. We also report that MBD2 binds to a subset of CpG island promoters that are characterized by the presence of active histone marks and RNA polymerase II (Pol2). At such sites, MBD2 binds downstream of th...
ORGANISM(S): Homo sapiens 
2014-07-03 | E-GEOD-54693 | biostudies-arrayexpress
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