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UnknownInsights into the molecular mechanism of dehalogenation catalyzed by D-2-haloacid dehalogenase from crystal structures.
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S-EPMC5780510 | biostudies-literature
ProteomicsA Bifunctional SPD-0090 contributes virulence of Streptococcus pneumoniae by affecting iron transport and galactose metabolism
Streptococcus pneumoniae (S.pneumoniae) is a Gram-positive bacterial pathogen that colonizes on the mucosal surfaces of the host's nasopharynx and upper respiratory tract and results in pneumonia. In order to survive and infect the host, S.pneumoniae must have obtain essential nutrients, such as tra...
ORGANISM(S): Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466) 
2022-06-01 | PXD030183 | Pride
Spd-0090 Virulence Iron transport protein Galactose metabolism Streptococcus pneumoniae 
ProteomicsProteomic Analysis on the Mechanism of Iron-Compensation Substitute for Manganese Deficiency of Streptococcus pneumoniae
Iron (Fe) and Manganese (Mn) are essential for bacterial survival and virulence as they are involved in catalysis, infection and biofilm formation. The basal metabolism of pathogenic bacteria would be disturbed by the deficiency of metal ions in the host environment. In this study, we found that Str...
ORGANISM(S): Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466) 
2023-09-30 | PXD008652 | Pride
Manganese deficiency Iron-compensation Proteomic Streptococcus pneumoniae 
ProteomicsPotential Role of Lysine Acetylation in Antibiotic Resistance of Escherichia coli
Antibiotic resistance is increasingly becoming a serious challenge to public health. The regulation of metabolism by post-translational modifications (PTMs) has been widely studied; however, the comprehensive mechanism underlying the regulation of acetylation in bacterial resistance against antibiot...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2022-10-14 | PXD030283 | Pride
Post-translational modification  escherichia coli  acetylation  pykf  antibiotic resistance 
ProteomicsCrizotinib, Tyrosine Kinase Inhibitors, Create an Antibacterial Active against Gram-positive Bacteria by Targeting the CTP Synthetase PyrG
Abstract The infection of drug resistant bacteria seriously threats to public health, which makes it more urgent to find novel antibacterial compounds. Compared with traditional development approaches, drug repurposing provides a faster and more effective strategy to find new antimicrobial agents....
ORGANISM(S): Staphylococcus aureus 
2022-03-10 | PXD029546 | Pride
Infection Pyrg Keywords: crizotinib Gram-positive 
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