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UnknownAn underlying mechanism for MleR activating the malolactic enzyme pathway to enhance acid tolerance in Lacticaseibacillus paracasei L9.
Tolerance to acid stress is a crucial property of probiotics against gastric acids. The malolactic enzyme pathway is one of the most important acid resistance systems in lactic acid bacteria. It has been reported that the malolactic enzyme pathway was regulated by the transcriptional regulator, MleR...
S-EPMC10537729 | biostudies-literature
UnknownQuercetin nanoformulation-embedded hydrogel inhibits osteopontin mediated ferroptosis for intervertebral disc degeneration alleviation.
Reactive oxygen species (ROS) play a pivotal role in multiple events during the progression of intervertebral disc degeneration (IDD). Hence, the precision treatment targets associated with ROS should be further explored to promote developing effective therapeutic strategies. In this study, by analy...
S-EPMC12235785 | biostudies-literature
UnknownTMPO-AS1 promotes cell proliferation of thyroid cancer via sponging miR-498 to modulate TMPO.

Background

Thyroid cancer (TC) is the most frequent endocrine malignancy. Long noncoding RNAs (lncRNAs) have been confirmed to act as significant roles in tumor development. The role of lncRNA TMPO-AS1 in TC is still unclear, so it remains to be explored. The aim of the research is to invest...
S-EPMC7346673 | biostudies-literature
UnknownTheoretical study of a highly fault-tolerant and scalable adaptive radiative cooler.
Conventional static radiative coolers have an unadjustable cooling capacity, which often results in overcooling in low temperature environment. Therefore, there is a great need for an adaptive dynamic radiative cooler. However, such adaptive coolers usually require complex preparation processes. Thi...
S-EPMC11501479 | biostudies-literature
UnknownRegulation Networks of Non-Coding RNA-Associated ceRNAs in Cisplatin-Induced Acute Kidney Injury.
Cisplatin is widely used as a chemotherapeutic drug to treat various solid tumors. However, it often induces severe side effects, including nephrotoxicity, which limits its application in clinical settings. Furthermore, the underlying mechanisms of action are unclear. Here, we applied whole-transcri...
S-EPMC9563924 | biostudies-literature
ProteomicsProteomics-Based Research on NnAP2 Regulation of Starch Content
The lotus is the most widely cultivated aquatic vegetable in China. Its underground stem (lotus root) is the primary edible part. Soluble sugars and starch are key quality indicators determining the texture and processing flavor of lotus root. Investigating the mechanism by which NnAP2 regulates sta...
ORGANISM(S): Solanum Tuberosum 
2025-12-24 | PXD071977 |
ProteomicsFlower morphology development in lotus ‘Sleeping Beauty'
these results provide an insight into the molecular networks underlying lotus floralorgan development and petaloid
ORGANISM(S): Nelumbo nucifera (Sacred lotus) 
2025-05-06 | PXD016222 | Pride
Petaloid Flower morphology Lotus 
UnknownELOVL gene family plays a virtual role in response to breeding selection and lipid deposition in different tissues in chicken (Gallus gallus).

Background

Elongases of very long chain fatty acids (ELOVLs), a family of first rate-limiting enzymes in the synthesis of long-chain fatty acids, play an essential role in the biosynthesis of complex lipids. Disrupting any of ELOVLs affects normal growth and development in mammals. Genetic v...
S-EPMC9575239 | biostudies-literature
UnknownZn (II) Porphyrin Built-in D-A Covalent Organic Framework for Efficient Photocatalytic H2 Evolution.
Covalent organic frameworks (COFs) with donor-acceptor (D-A) units are credible photocatalysts for their per-designed structure, inherent porosity, large surface area, splendid stability and so forth. Developing COFs with an excellent photocatalytic efficiency for hydrogen evolution is of a great si...
S-EPMC9696642 | biostudies-literature
UnknownEffect of Metoprolol Succinate in Patients with Stable Angina and Elevated Heart Rate Receiving Low-Dose β-Blocker Therapy.
Aims: β-blockers are underused in Chinese patients with coronary heart disease. The prescribed dose is often low. The aim of this study was to investigate the effect of metoprolol succinate doses of 95 mg and 190 mg on heart rate (HR) control, as well as drug tolerance, in Chinese patients wi...
S-EPMC5441040 | biostudies-literature
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