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MetabolomicsIntegrating Blood Microsampling Devices with CE-MS for Untargeted Analysis of Polar Metabolomics

Capillary electrophoresis–mass spectrometry (CE-MS) offers considerable advantages for polar compound metabolomics analysis, including simple workflows, fast method development, and suitability for small sample volumes. Blood microsampling (BμS) techniques (such as dried blood spots, quantitative...

2026-01-13 | MTBLS13090 | MetaboLights
MetabolomicsDual metal electrolysis in theta capillary for lipid analysis

Increasing studies associating glycerophospholipids with various pathological conditions highlight the need for their thorough characterization. However, the intricate composition of the lipidome due to the presence of lipid isomers poses significant challenges to structural lipidomics. This stud...

2023-10-10 | MTBLS8547 | MetaboLights
MetabolomicsWhole blood metabolomics of dementia patients reveal classes of disease-linked metabolites

Dementia is caused by factors that damage neurons. We quantified small molecular markers in whole blood of dementia patients, using non-targeted liquid chromatography-mass spectroscopy (LC-MS). Thirty-three metabolites, classified into 5 groups (A-E), differed significantly in dementia patients, ...

2021-07-06 | MTBLS2109 | MetaboLights
TranscriptomicsTranscriptional programs of lymphoid tissue capillary and high endothelium reveal control mechanisms for lymphocyte homing
This file contains gene microarray data from FACS purified mouse high endothelial cells and capillary endothelial cells from peripheral lymph nodes, mesenteric lymph nodes, and Peyer’s patches. The data will allow for better understanding of the specialization of high endothelial venules (HEV) and t...
ORGANISM(S): Mus musculus 
2014-08-31 | E-GEOD-58056 | biostudies-arrayexpress
MetabolomicsFrailty markers comprise blood metabolites involved in antioxidation, cognition, and mobility
As human society ages globally, age-related disorders are becoming increasingly common. Due to decreasing physiological reserves and increasing organ system dysfunction associated with age, frailty affects many elderly people, compromising their ability to cope with acute stressors. Frail elderly pe...
2020-05-01 | MTBLS1540 | MetaboLights
MetabolomicsDiverse metabolic reactions activated during 58-hr fasting are revealed by non-targeted metabolomic analysis of human blood
During human fasting, metabolic markers, including butyrates, carnitines, and branched-chain amino acids, are upregulated for energy substitution through gluconeogenesis and use of stored lipids. We performed non-targeted, accurate semiquantitative metabolomic analysis of human whole blood, plasma, ...
2019-09-11 | MTBLS549 | MetaboLights
MetabolomicsCharacterization of Whole Blood EVs Using PRotein Organic Solvent PRecipitation

Blood plays a vital role in diagnostic medicine by providing essential information for assessing health and diagnosing various conditions. Routine blood tests can reveal important biomarkers that support early diagnosis and timely intervention. Recently, extracellular vesicles (EVs) have emerged ...

2026-08-24 | MTBLS12801 | MetaboLights
MetabolomicsAnalyze the metabolic characteristics in fecal and peripheral blood plasma samples from different patient populations_blood

Given that hepatitis B virus (HBV)-related hepatocellular carcinoma (HBV-HCC) exhibits unique gut microbial and metabolic characteristics that influence the immunosuppressive tumor microenvironment, a better understanding of the correlations among gut microbiota, metabolism, and immunosuppressive...

2025-10-29 | MTBLS13231 | MetaboLights
MetabolomicsCharacterization of Blood Metabolites and the Uterine Microbiota in Estrus Simmental Cattle

Accurate oestrus detection is critical for optimizing reproductive efficiency in beef cattle, yet the underlying metabolic and microbial mechanisms remain poorly understood, particularly in Simmental cattle. To address this gap, we employed an integrated metabolomics and microbiome approach ...

2025-07-20 | MTBLS12755 | MetaboLights
MetabolomicsDeep insights into microsampling technologies for global lipidomic profiling of human whole blood using high-throughput LC-MS

In recent years, blood microsampling (BμS) technologies have gained popularity, as they offer simplicity, minimal invasiveness, and suitability for remote sample collection. In this study, the aim was to explore the potential of three BμS devices for reliable untargeted lipidomic profiling using ...

2025-09-30 | MTBLS10722 | MetaboLights
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