Metabolic networks are interconnected and influence diverse cellular processes. The protein-metabolite interactions that mediate these networks are frequently low affinity and challenging to systematically discover. We developed mass spectrometry integrated with equilibrium dialysis for the disco...

Processive catalysis is a fundamental molecular mechanism in nature to both build and dismantle complex biological polymers such as nucleic acids, proteins and carbohydrates, underpinning a broad spectrum of biotechnological applications. Here, we uncover a processive mechanism for the breakdown ...