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TranscriptomicsCardiogenic genes expressed in cardiac fibroblasts contribute to heart development and repair
Cardiac fibroblasts are critical to proper heart function through multiple interactions with the myocardial compartment. Loosely defined based on their mesenchymal origin, capacity to adhere to plastic and to secrete extracellular matrix, cardiac fibroblasts have been largely neglected due to hetero...
ORGANISM(S): Mus musculus 
2014-05-20 | E-GEOD-50531 | biostudies-arrayexpress
ProteomicsCombined genetic-pharmacologic inactivation of tightly linked ADAMTS proteases uncovers a requirement for versican and glypican-6 proteolysis in cardiac development.
Background: Extracellular matrix remodeling mechanisms are understudied in cardiac development and congenital heart defects. Two similar matrix-degrading metalloproteases, ADAMTS1 and ADAMTS5, are extensively co-expressed during mouse cardiac development. The mouse mutants of each have mild cardiac ...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD045706 | Pride
Proteomics Cardiac jelly Proteases Tetralogy of fallot Proteoglycan Trabeculation 
ProteomicsCombined genetic-pharmacologic inactivation of tightly linked ADAMTS proteases uncovers a requirement for versican and glypican-6 proteolysis in cardiac development-1
Background: Extracellular matrix remodeling mechanisms are understudied in cardiac development and congenital heart defects. Two similar matrix-degrading metalloproteases, ADAMTS1 and ADAMTS5, are extensively co-expressed during mouse cardiac development. The mouse mutants of each have mild cardiac ...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2025-05-06 | PXD045868 | Pride
Proteomics Cardiac jelly Proteases Tetralogy of fallot Proteoglycan Trabeculation 
TranscriptomicsHuman iPSC-derived cardiomyocytes under hypoxia/normoxia, treated with bone marrow or cardiac stromal cell extracellular vesicles
RNA-seq was performed on cultured human induced pluripotent cell derived cardiomyocytes (iPSC-CMs). There are four groups, with three samples per group: H1,H2,H3. Negative control. Healthy, normoxic iPSC-CMs D1,D2,D3. Positive control. iPSCs cultured under hypoxic (0-1% O2) for 48h with 2% v/v PBS ...
ORGANISM(S): Homo sapiens 
2024-10-02 | E-MTAB-13966 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA-seq of Pdgfra+/Sca1+/Cd31- mouse cardiac cells
Adult mice hearts contain a population of resident mesenchymal stem cell (MSC)-like cells called cardiac colony forming units-fibroblast (cCFU-F). The cCFU-F are housed in a population of non-muscle cardiac cells that are Pdgfra+/Sca1+/Cd31- (S+P+ fraction). The goal of this experiment was to profil...
ORGANISM(S): Mus musculus 
2019-03-28 | E-MTAB-7365 | biostudies-arrayexpress
TranscriptomicsA Comparison of the Efficacy of Transplantation of Bone Marrow Derived Mesenchymal Stem Cells and Unrestricted Somatic Stem Cells on Outcome After Acute Myocardial Infarction
Unrestricted Somatic Stem Cells (USSC) are a cell population derived from umbilical cord blood. They have been shown to have greater plasticity than mesenchymal stem cells, and are being investigated as a therapeutic option for many disease states, including cardiovascular disease.

In this st...
ORGANISM(S): Homo sapiens 
2012-08-24 | E-MEXP-3638 | biostudies-arrayexpress
UnknownEffects of Serial Passage on the Characteristics and Cardiac and Neural Differentiation of Human Umbilical Cord Wharton's Jelly-Derived Mesenchymal Stem Cells.
Not available
S-EPMC4699056 | biostudies-literature
UnknownHuman Wharton's Jelly-Derived Mesenchymal Stem Cells Minimally Improve the Growth Kinetics and Cardiomyocyte Differentiation of Aged Murine Cardiac c-kit Cells in In Vitro without Rejuvenating Effect.
Not available
S-EPMC6887783 | biostudies-literature
TranscriptomicsMicrostructures regulate distant cellular interactions during heart formation
Communication between endocardium and myocardium, separated by cardiac jelly, is essential for cardiac morphogenesis. How membrane-localized receptors and ligands achieve interaction across the cardiac jelly is not understood. Utilizing a number of approaches, including genetic labeling of cell-cell...
ORGANISM(S): Mus musculus 
2024-12-01 | GSE279629 | GEO
UnknownEpicardial CCM2 Promotes Cardiac Development and Repair Via its Regulation on Cytoskeletal Reorganization.
Not available
S-EPMC10950406 | biostudies-literature
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