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TranscriptomicsModulation of calcium activated potassium channels induces cardiogenesis of pluripotent stem cells and enrichment of pacemaker- like cells
Background: Ion channels are key determinants for the function of excitable cells but little is known about their role and involvement during cardiac development. Earlier work identified Ca2+-activated potassium channels of small and intermediate conductance (SKCas) as important regulators of neural...
ORGANISM(S): Mus musculus 
2011-01-03 | E-GEOD-18660 | biostudies-arrayexpress
UnknownNoncanonical electromechanical coupling paths in cardiac hERG potassium channel.
Not available
S-EPMC9971164 | biostudies-literature
TranscriptomicsTranscription profiling of mouse Kir6.1-deficient heart following LPS challenge
KATP opposes depolarization of cells in the heart, smooth muscle, and other tissues by permitting the efflux of potassium ions and this efflux is evidently required to prevent unopposed vasoconstriction and insufficiency of coronary artery blood flow triggered by one or more cytokines induced in res...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7605 | biostudies-arrayexpress
ProteomicsTitin-dependent transient ventricular defects result in adult atrial arrhythmia and impaired contractility
Atrial fibrillation (AF), the most common arrhythmia, is occasionally associated with cardiac developmental defects, but causal relationships are poorly defined. Importantly, functional compensation for developmental defects may mask increased risk of arrhythmia in adults. Here, we deleted 9 amino a...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2024-08-09 | PXD038300 | Pride
Titin Cardiac potassium channel Atrial fibrillation Zebrafish 
UnknownCalmodulin acts as a state-dependent switch to control a cardiac potassium channel opening.
Not available
S-EPMC7732179 | biostudies-literature
UnknownMutations in the potassium channel subunit KCNE1 are associated with early-onset familial atrial fibrillation.
Not available
S-EPMC3359244 | biostudies-literature
UnknownGenetic Variants in Potassium Channel Genes and Their Clinical Implications in Kazakhstani Patients with Cardiac Arrhythmias.
Not available
S-EPMC12942129 | biostudies-literature
TranscriptomicsTranscriptomic alterations in Trypanosoma cruzi-infected cardiac myocytes
Trypanosoma cruzi infection is a major cause of cardiomyopathy. Gene profiling studies of hearts from infected mice have revealed prominent changes in gene expression within many functional pathways. This variety of transcriptomic changes in infected mice raises the question of whether gene express...
ORGANISM(S): Mus musculus 
2010-05-15 | E-GEOD-17330 | biostudies-arrayexpress
UnknownSingle-channel basis for the slow activation of the repolarizing cardiac potassium current, I(Ks).
Not available
S-EPMC3600500 | biostudies-literature
UnknownThe two-pore domain potassium channel TREK-1 mediates cardiac fibrosis and diastolic dysfunction.
Not available
S-EPMC6205385 | biostudies-literature
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