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TranscriptomicsEpigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis
Adult-onset diseases can be associated with in utero events, but mechanisms for such temporally distant dysregulation of organ function remain unknown. The polycomb histone methyltransferase, Ezh2, stabilizes transcription by depositing repressive histone marks during development that persist into ...
ORGANISM(S): Mus musculus 
2011-12-31 | E-GEOD-30076 | biostudies-arrayexpress
TranscriptomicsCardiogenic genes expressed in cardiac fibroblasts contribute to heart development and repair
Cardiac fibroblasts are critical to proper heart function through multiple interactions with the myocardial compartment. Loosely defined based on their mesenchymal origin, capacity to adhere to plastic and to secrete extracellular matrix, cardiac fibroblasts have been largely neglected due to hetero...
ORGANISM(S): Mus musculus 
2014-05-20 | E-GEOD-50531 | biostudies-arrayexpress
TranscriptomicsGlobal gene expression profiles of cardiac progenitors differentiated from human pluripotent stem cells in 3D culture under simulated microgravity
Methods: RNA-seq libraries were prepared using the Illumina TruSeq RNA kit and the TrueSeq method was employed for mRNA enrichment. The libraries were quantified and samples were multiplexed in each lane of the flowcell. Cluster generation was performed and then sequenced on the Illumina HiSeq1000 s...
ORGANISM(S): Homo sapiens 
2016-08-08 | E-GEOD-84582 | biostudies-arrayexpress
TranscriptomicsCardiac precursor differentiation from hESCs by lentiviral promoter drug selection
Several of the essential core transcriptional control elements in human embryonic stem cells (ESCs) have been identified, but the production and function of alternative isoforms in self-renewal, pluripotency and tissue lineage specification remain largely unknown. We have modified the H9 ESC line to...
ORGANISM(S): Homo sapiens 
2008-10-24 | E-GEOD-13297 | biostudies-arrayexpress
TranscriptomicsGene expression in mouse embyonic cardiomyocytes, fibroblasts and adult cardiac fibroblasts
Growth and expansion of ventricular chambers is essential during cardiogenesis and is achieved by proliferation of cardiac progenitors that are not fully differentiated. Disruption of this process can lead to prenatal lethality. In contrast, adult cardiomyocytes achieve growth through hypertrophy ra...
ORGANISM(S): Mus musculus 
2009-01-14 | E-GEOD-14412 | biostudies-arrayexpress
TranscriptomicsBMP-mediated inhibition of FGF signaling promotes cardiomyocyte differentiation of anterior heart field progenitors
The transition from progenitor to differentiated cells is critical for successful organogenesis; subtle alterations in this process can lead to developmental disorders. The anterior heart field (AHF) encompasses a niche in which cardiac progenitors maintain their multipotent and undifferentiated nat...
ORGANISM(S): Gallus gallus 
2010-08-01 | E-GEOD-19698 | biostudies-arrayexpress
TranscriptomicsPharyngeal mesoderm regulatory network controls cardiac and head muscle morphogenesis
The search for developmental mechanisms driving vertebrate organogenesis has paved the way toward a deeper understanding of birth defects. During embryogenesis, parts of the heart and craniofacial muscles arise from pharyngeal mesoderm (PM) progenitors. Here, we reveal a hierarchical regulatory netw...
ORGANISM(S): Mus musculus 
2012-11-26 | E-GEOD-42389 | biostudies-arrayexpress
ProteomicsSecretome containing extracellular vesicles (EV) from cardiovascular progenitors (EV-CPC) vs the secretome containing EV from Fibroblasts (EV-FB)
Secretome containing extracellular vesicles (EV) seem to mediate the benefits of cell therapy for ischemic heart failure. Our project has the objective of comparing the secretome containing extracellular vesicles (EV) from cardiac progenitor cells (EV-CPC) vs the secretome containing EV from Fibrobl...
ORGANISM(S): Homo sapiens (Human) 
2023-09-22 | PXD022129 | Pride
Extracellular vesicles (ev) Fibroblasts Secretome from cardic progenitors Cardiovascular progenitor cells (cpc) 
TranscriptomicsCardiac adiposity is regulated by Klf4 and c-Myc
In this study, we examined if KLF4 and c-MYC (KM)-transduced murine cardiac mesenchymal progenitors (CMPs) played a role in the differentiation into adipocytes in the absence of adipogenic stimulation cocktails. These progenitors exhibited increased expression of adipogenic-related genes, such as C/...
ORGANISM(S): Mus musculus 
2015-09-01 | E-GEOD-70088 | biostudies-arrayexpress
GenomicsRNA sequencing of hPSC-derived cardiac progenitors and endocardium
RNA sequencing of hPSC-derived cardiac progenitors and endocardium
PRJNA427332 | ENA
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