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MetabolomicsFOXK1 and FOXK2 Promote Cardiomyocyte Proliferation and Heart Regeneration
Promoting the proliferation of endogenous cardiomyocytes represents a promising strategy for treating cardiac injuries. Identifying key factors that regulate cardiomyocyte proliferation can advance the development of novel therapies for heart regeneration. Here we identify that FOXK1 and FOXK2 act a...
2025-02-13 | MTBLS12191 | MetaboLights
TranscriptomicsTranscriptional Reversion of Cardiac Myocyte Fate During Mammalian Cardiac Regeneration.
Rationale: Neonatal mice have the capacity to regenerate their hearts in response to injury, but this potential is lost after the first week of life. The transcriptional changes that underpin mammalian cardiac regeneration have not been fully characterized at the molecular level. Objective: The obje...
ORGANISM(S): Mus musculus 
2014-12-20 | E-GEOD-64403 | biostudies-arrayexpress
MetabolomicsMRG15 orchestrates glycolysis and the pentose phosphate pathway to facilitate heart regeneration following myocardial infarction
Metabolic reprogramming is crucial for adult heart regeneration after myocardial infarction (MI). Here, we identify the MORF4-related gene on chromosome 15 (MRG15) as a key orchestrator of cardiomyocyte metabolism to drive cardiomyocyte proliferation. MRG15 expression is upregulated in both hypoxic ...
2026-09-22 | MTBLS15770 | MetaboLights
MetabolomicsMRG15 orchestrates glycolysis and the pentose phosphate pathway to facilitate heart regeneration following myocardial infarction
Metabolic reprogramming is crucial for adult heart regeneration after myocardial infarction (MI). Here, we identify the MORF4-related gene on chromosome 15 (MRG15) as a key orchestrator of cardiomyocyte metabolism to drive cardiomyocyte proliferation. MRG15 expression is upregulated in both hypoxic ...
2026-09-22 | MTBLS15769 | MetaboLights
TranscriptomicsZebrafish heart regeneration
Ischemic cardiopathy is the leading cause of death in the world, for which efficient regenerative therapy is not currently available. In mammals, after a myocardial infarction episode, the damaged myocardium is replaced by scar tissue featuring collagen deposition and tissue remodelling with negligi...
ORGANISM(S): Danio rerio 
2010-03-09 | E-GEOD-17993 | biostudies-arrayexpress
TranscriptomicsMicroarray Analysis of microRNA Expression during Notophthalmus viridescens (red-spotted newt) heart regeneration
The adult vertebrate red spotted newt is a champion of regeneration, demonstrating an amazing ability to regenerate damaged organs and tissues back to an uninjured state without the formation of scar or reduction in function. By developing a novel cardiac resection strategy, our group recently demon...
ORGANISM(S): Notophthalmus viridescens 
2013-09-24 | E-GEOD-44547 | biostudies-arrayexpress
TranscriptomicsGenomeâ??wide transcriptional profiling with spatial resolution identifies Bone Morphogenetic Protein signaling as essential regulator of zebrafish cardiomyocyte regeneration.
In contrast to mammals, zebrafish regenerate heart injuries via proliferation of cardiomyocytes located at the wound border. Here, we show that tomo-seq can be used to identify whole-genome transcriptional profiles of the injury zone, the border zone and the healthy myocardium. Interestingly, the bo...
ORGANISM(S): Danio rerio 
2016-01-11 | E-GEOD-74652 | biostudies-arrayexpress
TranscriptomicsTranscription profiling time series of Danio rerio heart regeneration
Amputation of heart tissue followed by regeneration of the heart. Samples were taken at 0 hpa (hours post-amputation), 6 hpa, 12 hpa, 24 hpa, 3 dpa and 5 dpa.
ORGANISM(S): Danio rerio 
2008-09-05 | E-MEXP-1239 | biostudies-arrayexpress
TranscriptomicsSingle epicardial cell transcriptome sequencing identifies Caveolin-1 as an essential factor in zebrafish heart regeneration
By contrast with mammals, adult zebrafish have a high capacity to regenerate damaged or lost myocardium through proliferation of spared cardiomyocytes. The epicardial sheet covering the heart is activated by injury and aids muscle regeneration through paracrine effects and as a multipotent cell sou...
ORGANISM(S): Danio rerio 
2015-12-15 | E-GEOD-75583 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiling times series of zebrafish heart regeneration
The zebrafish has the capacity to regenerate its heart after severe injury. While the function of a few genes during this process has been studied, we are far from fully understanding how genes interact to coordinate heart regeneration. To enable systematic insights into this phenomenon, we generate...
ORGANISM(S): Danio rerio 
2016-06-01 | E-GEOD-67665 | biostudies-arrayexpress
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