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TranscriptomicsmiRNAs high throughput sequencing profiling of basals cells and columnar cells
The airway mucociliary epithelium is consituted of three main cell types : columnar ciliated plus secretory cells and basal cells. Columnar cells are represented by a great majority of ciliated cells. We used Cell sorting by FACSaria to separate basal cells from ciliated and secreting columnar cell...
ORGANISM(S): Homo sapiens 
2011-06-06 | E-GEOD-22145 | biostudies-arrayexpress
UnknownHIV-Infected Spleens Present Altered Follicular Helper T Cell (Tfh) Subsets and Skewed B Cell Maturation.
Not available
S-EPMC4621058 | biostudies-literature
UnknownTLR-9 agonist and CD40-targeting vaccination induces HIV-1 envelope-specific B cells with a diversified immunoglobulin repertoire in humanized mice.
Not available
S-EPMC7728200 | biostudies-literature
TranscriptomicsmiRNAs high throughput sequencing profiling of regenerating human airway epithelial cells
The regeneration of the airway mucociliary epithelium involves several sequential events including migration, proliferation, polarization and final differentiation (i.e ciliogenesis). The airway mucociliary epithelium is consituted of three main cell types : ciliated cells, secretory cells and basal...
ORGANISM(S): Homo sapiens 
2011-06-06 | E-GEOD-22144 | biostudies-arrayexpress
TranscriptomicsmicroRNAs signatures of Xenopus laevis embryo epidermis at stage 11 (non ciliated) and 26 (ciliated) using high throughput sequencing
Epidermis of Xenopus embryos forms a mucociliary epithelium constituted of basal, scattered, secreting and ciliated cells and is histologically similar to human airway mucociliary epithelium. We compared microRNAs signatures of epidermis of Xenopus embryos at stage 11.5 (gastrula, non ciliated epide...
ORGANISM(S): Xenopus laevis 
2011-06-06 | E-GEOD-22146 | biostudies-arrayexpress
TranscriptomicsMicroRNA signature during the time course of regeneration of the human airway mucociliary epithelium
The regeneration of the airway mucociliary epithelium involves several sequential events including migration, proliferation, polarization and final differentiation (i.e ciliogenesis). The airway mucociliary epithelium is consituted of three main cell types : ciliated cells, secretory cells and basal...
ORGANISM(S): Homo sapiens 
2011-06-06 | E-GEOD-22141 | biostudies-arrayexpress
TranscriptomicsTranscriptomic impact of microRNAs-449 or microRNAs-34 overexpression in proliferating human airway epithelial cells
We used microarrays to detail the global programme of gene expression that occurs in response to miR-449 or miR-34 overexpression in proliferating HAECs. Each donors were transfected with pre-miR-Negative control, pre-miR-449a and pre-miR-449b. The donors 3 and 4 were morever transfected with pre-mi...
ORGANISM(S): Homo sapiens 
2011-06-06 | E-GEOD-22143 | biostudies-arrayexpress
TranscriptomicsDescription of the microRNA repertoire of leucocytes of patients suffering from atypical myeloproliferative syndromes
Atypical Myeloproliferative Neoplasms (aMPN) share characteristics of MPN and Myelodysplastic Syndromes (MDS). Although anomalies of tyrosine-kinases or proteins involved in cytokine signaling are common in MPN, the pathophysiology of atypical MPN is still elusive. Since deregulation of microRNAs ha...
ORGANISM(S): Homo sapiens 
2016-09-01 | E-GEOD-75666 | biostudies-arrayexpress
TranscriptomicsGene expression signature of MYB-GATA overexpression plus GATA1 down regulation in undifferentiated or differentiated UT7 cells
Acute basophilic leukemia is a rare subtype of acute myeloblastic leukemia. We recently described a recurrent t(X;6)(p11;q23) translocation occurring in male infants with acute basophilic leukemia, generating a MYB-GATA1 fusion gene. To better understand the role of MYB-GATA1 in the leukemogenesis o...
ORGANISM(S): Homo sapiens 
2016-09-01 | E-GEOD-72913 | biostudies-arrayexpress
TranscriptomicsEffect of Imatinib (1microM, 24 hours) on the microRNA repertoire of chronic myeloid leukemia cell line K562
Using a microarray-based miRNA profiling, we found in a model of chronic myeloid leukemia (CML) that the activity of the oncoprotein BCR-ABL1 regulates the expression of miR-21, a "onco-microRNA" known to be overexpressed in numerous cancers. This relies on the phosphorylation status of ST...
ORGANISM(S): Homo sapiens 
2016-09-01 | E-GEOD-78037 | biostudies-arrayexpress
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