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R. conorii (pathogenic) and R. montanensis (non-pathogenic) display opposite survival versus death phenotypes in macrophage-like cells, respectively. We herein employed a global transcriptomic profiling of host responses to infection (1hpi) of human THP-1 macrophages with R. conorii and R. montanens...
ORGANISM(S): Homo sapiens 
Pericentric heterochromatin (PCH) forms spatially and temporarily distinct compartments from other nuclear fractions and plays an important role in nuclei organization and genome stability. This highlights the necessity of elucidating the protein compositions of PCH. We find that the PCH compartment...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-23 | PXD045223 | Pride
Details of the experiment are available within the Nucleic Acid Research, 2004 manuscript "Genomic profiling by DNA amplification of laser capture microdissected tissues and array CGH", by Cardoso J. et al.
ORGANISM(S): Homo sapiens 
Expression profiling is a well established tool for the genome-wide analysis of the transcriptional activity of human neoplasia. However, the high sensitivity of this approach combined with the well-known cellular and molecular heterogeneity of cancer often result in extremely complex and extended e...
ORGANISM(S): Homo sapiens 

INTRODUCTION: Although sarcopenia greatly affects health and quality of life in older people, its pathophysiological causes are not fully elucidated. To face this challenge, omics technologies can be used. The metabolome gives a vision of the interaction between the genome and t...

2021-09-29 | MTBLS2679 | MetaboLights
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