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TranscriptomicsConserved nutrient sensor O-GlcNAc transferase is integral to the C. elegans pathogen-specific immune response
Discriminating pathogenic bacteria from energy-harvesting commensals is key to host immunity. Using mutants defective in the enzymes of O-linked N-acetylglucosamine (O-GlcNAc) cycling, we examined the role of this nutrient-sensing pathway in the Caenorhabidits elegans innate immune response. Using w...
ORGANISM(S): Caenorhabditis elegans 
2015-05-01 | E-GEOD-53732 | biostudies-arrayexpress
TranscriptomicsCooperative blockade of CK2 and ATM kinases drives apoptosis in VHL-deficient renal carcinoma cells / RNA-seq (BRB-seq) of treated 786-O spheroids
Multicellular Tumor Spheroids (MCTS) were pre-formed for 3 days with 786-O cell line to better mimic the tumor microenviroenment. These spheroids were treated with either vehicle (DMSO), drugs alone (KU-60019 10 μM; CX-4945 5 μM) or in combination (KU + CX) for 48h before RNA extraction.
ORGANISM(S): Homo sapiens 
2021-02-04 | E-MTAB-9977 | biostudies-arrayexpress
TranscriptomicsATAC-seq in the differentiation system ESC to NPC upon O-GlcNAc removal
This experiment uses a transgenic cell line expressing bacterial OGA BtGH84 fused to a localization peptide (NLS) and regulated by Tet-On system. OGA is a glycosidase that removes O-GlcNAc modifications. We evaluated the changes in chromatin openness before and after O-GlcNac removal by OGA.
ORGANISM(S): Mus musculus 
2024-08-31 | E-MTAB-14350 | biostudies-arrayexpress
GenomicsChIP-seq O-GlcNac in mouse ES cells
Analysis of O-GlcNac occupancy on chromatin in mouse ES cells by ChIP-seq
ORGANISM(S): Mus musculus 
2024-08-31 | E-MTAB-14310 | biostudies-arrayexpress
TranscriptomicsCutnRun of O-GlcNac in mouse ES cells in high glucose condition
Study of the chromatin occupancy of O-GlcNac in mouse ES cells cultivated in a high glucose concentration media
ORGANISM(S): Mus musculus 
2024-08-31 | E-MTAB-14308 | biostudies-arrayexpress
TranscriptomicsCutnRun of O-GlcNac in mouse ES cells in low glucose condition at 6 hours, 8 hours, and 1 week
Study of the chromatin occupancy of O-GlcNac in mouse ES cells cultivated in low glucose condition at 6 hours, 8 hours, and 1 week
ORGANISM(S): Mus musculus 
2024-08-31 | E-MTAB-14309 | biostudies-arrayexpress
TranscriptomicsCutnRun directed against O-GlcNac in the human DLD-1 cell line with doxycycline treatment to induce RNA Polymerase II degradation
This experiment aimed at investigating how O-GlcNac occupancy sites are impacted by RNA Polymerase II removal upon doxycycline stimulation. These human colon adenocarcinoma DLD-1 cells express OsTIR and a cassette encoding mini-AID (mAID) and fluorescent protein mClover (mAID+mClover) at the initiat...
ORGANISM(S): Homo sapiens 
2024-08-31 | E-MTAB-14307 | biostudies-arrayexpress
TranscriptomicsRNA-seq from tibialis muscles from rats aged 15 months (adult) and 27 months (old)
To gain new insights into molecular changes in skeletal muscle aging and disease with a special focus on differential alternative splicing and senescence, we performed RNA-seq on tibialis muscles from 15 months old (adult, a) and 27 months old (old, o) rats. Whole (w) muscle samples were prepared fo...
ORGANISM(S): Rattus norvegicus 
2021-06-26 | E-MTAB-10582 | biostudies-arrayexpress
ProteomicsComprehensive evaluation of cleavable bioorthogonal probes for site-specific O-GlcNAc proteomics
O-linked β-N-acetylglucosamine (O-GlcNAc) modification (i.e., O-GlcNAcylation) on proteins is an essential modification in physiology and pathology. Although O-GlcNAcylation is functionally critical, its analysis has never been an easy task. Despite the existence of a number of methods developed in ...
ORGANISM(S): Mus musculus (Mouse) 
2025-10-20 | PXD063995 | Pride
Mouse brain O-glcnac Click chemistry Lc-ms/ms 
ProteomicsProteomic analysis revealed gender-related differences in the skin mucus proteome of discus fish (Symphysodon haraldi) during the parental and non-parental care periods
The discus fish, Symphysodon spp., a South American cichlid, has a unique parental care behavior where fry bite on parental skin mucus after hatching. In this study, we used LC-MS/MS technique to compare the skin mucus proteome composition of male or female discus fish during parental and non-parent...
ORGANISM(S): Symphysodon Haraldi 
2024-08-15 | PXD054942 |
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