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MetabolomicsECM deposition is driven by caveolin1-dependent regulation of exosomal biogenesis and cargo sorting

The composition and physical properties of the extracellular matrix (ECM) critically influence tumor progression, but the molecular mechanisms underlying ECM layering are poorly understood. Tumor-stroma interaction is critically dependent on cell-cell communication mediated by exosomes, small ves...

2020-10-07 | MTBLS1969 | MetaboLights
MetabolomicsECM deposition is driven by caveolin1-dependent regulation of exosomal biogenesis and cargo sorting

The composition and physical properties of the extracellular matrix (ECM) critically influence tumor progression, but the molecular mechanisms underlying ECM layering are poorly understood. Tumor-stroma interaction is critically dependent on cell-cell communication mediated by exosomes, small ves...

2020-10-07 | MTBLS1977 | MetaboLights
MetabolomicsMembrane lipid as cofactor of cargo uptake and release by box-like lipid transfer proteins
Lipid transfer proteins (LTPs) shuttle their cargo lipids between cellular membranes. LTPs facilitate the costly extraction of a lipid from a donor membrane, and its delivery into the acceptor membrane, but the mechanisms remain poorly understood. We combined extensive molecular dynamics simulations...
2026-10-06 | MTBLS15933 | MetaboLights
ProteomicsExtensive structural rearrangement of intraflagellar transport trains underpins bidirectional cargo transport
Bidirectional transport in cilia is carried out by polymers of the IFTA and IFTB protein complexes, referred to as anterograde and retrograde IFT “trains”. Anterograde trains deliver cargoes from the cell to the ciliary tip, then remodel into retrograde trains for cargo export. We set out to underst...
ORGANISM(S): Chlamydomonas Reinhardtii 
2024-08-21 | PXD049195 | JPOST Repository
ProteomicsExtensive structural rearrangement of intraflagellar transport trains underpins bidirectional cargo transport (Proteomics
Bidirectional transport in cilia is carried out by polymers of the IFTA and IFTB protein complexes, referred to as anterograde and retrograde IFT “trains”. Anterograde trains deliver cargoes from the cell to the ciliary tip, then remodel into retrograde trains for cargo export. We set out to underst...
ORGANISM(S): Chlamydomonas Reinhardtii 
2024-08-21 | PXD049260 | JPOST Repository
TranscriptomicsBAG6KO impacts extracellular vesicle mRNA cargo
The mRNA cargo of B-16V and B-16V-delta-BAG6 cells was sequenced with RNA seq.
ORGANISM(S): Mus musculus 
2019-11-29 | E-MTAB-7123 | biostudies-arrayexpress
ProteomicsMGAT3 and MGAT5 overexpression alters the protein cargo of extracellular vesicles released by metastatic melanoma cells
Extracellular vesicles (EVs) are potential non-invasive diagnostic, prognostic, and therapeutic tools. Additionally, they are important contributors to tumorigenesis. Glycosylation has been found to modulate the composition of the EV proteome, and increased amounts of beta 1,6-branched N-glycans, sy...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-11-08 | MSV000096340 | MassIVE
TranscriptomicsExosome RNA cargo in activated liver stellate cells
Previously we have described the role of liver stellate cell exosomes in triggering macrophage migration and immune activation, we wanted to study what cargo in this exosomes were responsible for such activation. We found a few interesting mRNAs and siRNAs involved in the immune response pathway and...
ORGANISM(S): Homo sapiens 
2022-01-31 | E-MTAB-11373 | biostudies-arrayexpress
GenomicsBAG6KO impacts extracellular vesicle mRNA cargo
BAG6KO impacts extracellular vesicle mRNA cargo
PRJEB28086 | ENA
ProteomicsCargo analysis of autophagic bodies in Saccharomyces cerevisiae
Isolated yeast autophagic bodies and the total cell lysate were analyzed by mass spectrometry.
ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast) 
2024-08-22 | PXD052405 | JPOST Repository
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