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Transcriptomics1,25(OH)2D3 time course in THP-1 cells
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2016-07-03 | E-GEOD-69303 | biostudies-arrayexpress
TranscriptomicsVitamin D receptor (VDR) target genes in THP-1 monocytic leucemia cells
The biologically active form of vitamin D, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), is a direct regulator of gene transcription, since it is the only high affinity natural ligand of the transcription factor vitamin D receptor (VDR). Transcriptome-wide analysis of THP-1 human monocyte-like cells had i...
ORGANISM(S): Homo sapiens 
2015-04-26 | E-GEOD-60102 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of vitamin D receptor (VDR) target genes in THP-1 monocytic leucemia cells
Identification of primary target genes of vitamin D receptor (VDR) in an immune-related cellular model (THP-1 cells) to study, in conjunction with VDR binding data from ChIP-seq, the genome-wide mechanisms of transcriptional regulation by VDR. THP-1 cells were treated 4 h either with 0.1% ethanol (v...
ORGANISM(S): Homo sapiens 
2011-08-16 | E-GEOD-27270 | biostudies-arrayexpress
GenomicsPatterns of genome-wide VDR locations
The genome-wide analysis of the binding sites of the transcription factor vitamin D receptor (VDR) is essential for a global appreciation the physiological impact of the nuclear hormone 1M-NM-1,25-dihydroxyvitamin D3 (1,25(OH)2D3). Genome-wide analysis of lipopolysaccharide (LPS)-polarized THP-1 hu...
ORGANISM(S): Homo sapiens 
2014-11-14 | E-GEOD-53041 | biostudies-arrayexpress
TranscriptomicsProfiling of promoter occupancy by PPARM-NM-1 in human hepatoma cells via ChIP-chip analysis
The transcription factor Peroxisome Proliferator-Activated Receptor M-NM-1 (PPARM-NM-1) is an important regulator of hepatic lipid metabolism. While PPARM-NM-1 is known to activate transcription of numerous genes, no comprehensive picture of PPARM-NM-1 binding to endogenous genes has yet been report...
ORGANISM(S): Homo sapiens 
2010-11-23 | E-GEOD-25547 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of human monocytic THP-1 cell treated with 1α,25-dihydroxyvitamin D3 or Trichostatin A and the combination of both
The nuclear hormone 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3) regulates its target genes via activation of the transcription factor vitamin D receptor (VDR) far more specifically than the chromatin modifier trichostatin A (TsA) via its inhibitory action on histone deacetylases. We selected the thro...
ORGANISM(S): Homo sapiens 
2012-10-25 | E-GEOD-36323 | biostudies-arrayexpress
GenomicsCTCF ChIP-seq in human monocytic THP-1 cells
ChIP-seq for the insulator protein CTCF in THP-1 cells after stimulation with the the natural VDR ligand 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) THP-1 cells were treated for 24 h with 100 nM 1,25(OH)2D3 before ChIP assay
ORGANISM(S): Homo sapiens 
2016-07-04 | E-GEOD-69962 | biostudies-arrayexpress
GenomicsFAIRE-seq 1,25(OH)2D3 time course in THP-1 cells
Assessment of regions of open chromatin by FAIRE-seq in THP-1 cells treated with 1,25(OH)2D3 for 0-48 h Three independent experiments of 1,25(OH)2D3 time course in THP-1 cells
ORGANISM(S): Homo sapiens 
2016-07-04 | E-GEOD-69297 | biostudies-arrayexpress
TranscriptomicsRNA-seq 1,25(OH)2D3 time course in THP-1 cells
gene expression profiling by RNA-seq in THP-1 cells treated with 1,25(OH)2D3 for 2.5-24 h three independent experiments of 1,25(OH)2D3 time course in THP-1 cells
ORGANISM(S): Homo sapiens 
2016-07-04 | E-GEOD-69284 | biostudies-arrayexpress
GenomicsGenome-wide landscape of liver X receptor chromatin binding and gene regulation
Gene expression: Identification of primary target genes of liver X receptor (LXR) in an immune-related cellular model (THP-1 cells) to study, in conjunction with LXR binding data from ChIP-seq, the genome-wide mechanisms of transcriptional regulation by LXR. ChIP-Seq: We performed ChIP-seq in macro...
ORGANISM(S): Homo sapiens 
2012-02-02 | E-GEOD-28319 | biostudies-arrayexpress
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