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TranscriptomicsTranscription profiling of mouse cells expressing tet inducible LhX2, withdrawal of LHX2 over time was analysed
Expression of the lim-homeodomain transcription factor is required for sustained maintenance of heamatopoietic stem cell like cells in undifferentiated form durng in vitro culturing. Cell lines were created from the mouse embryonic stem (ES) cell line, Ainv15. The gene Lhx2 was introducted into thes...
ORGANISM(S): Mus musculus 
2005-12-19 | E-MEXP-431 | biostudies-arrayexpress
TranscriptomicsEffect of insulin infusion on human skeletal muscle
To identify insulin responsive genes in humans, in the first protocol, skeletal muscle biopsies from six non-diabetic subjects were obtained before and after a two-hour of hyperinsulinaemic (infusion rate 40 mU/m2/min) euglycemic clamp. A variable infusion of glucose (180 g/l) enriched with tritiate...
ORGANISM(S): Homo sapiens 
2007-03-01 | E-GEOD-7146 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human skeletal muscle from males with type 2 diabetes to identify genes involved in oxidative phosphorylation
DNA microarrays can be used to discover gene expression changes characteristic of human disease. This is challenging, however, when relevant differences are subtle at the level of individual genes. We introduce an analytical strategy, Gene Set Enrichment Analysis, designed to detect modest but coord...
ORGANISM(S): Homo sapiens 
2007-07-17 | E-CBIL-30 | biostudies-arrayexpress
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