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ProteomicsProteome of L-carnitine-grown Eubacterium limosum ATCC 8486
Eubacterium limosum ATCC 8486 makes acetate and butyrate from various substrates and is found in the human intestine. The proteome of L-carnitine-grown Eubacterium limosum was obtained in order to identify enzymes required for growth on L-carnitine, in particular to identify components that are uniq...
ORGANISM(S): Eubacterium limosum Bacteria 
2020-06-19 | PXD013961 | Pride
Carnitine demethylation Human gut isolate Acetogenic bacteria 
GenomicsDNA demethylation by Tet dioxygenases controls gastrula patterning by regulating Lefty-Nodal signaling
Mammalian genomes are subjected to epigenetic modifications, including cytosine methylation by DNA methyltransferases (Dnmt) and further oxidation by Ten-eleven-translocation (Tet) family of dioxygenases. Cytosine methylation plays key roles in multiple processes such as genomic imprinting and X-chr...
ORGANISM(S): Mus musculus 
2016-10-27 | E-GEOD-76261 | biostudies-arrayexpress
ProteomicsProteome of choline-grown Eubacterium limosum ATCC 8486
Eubacterium limosum ATCC 8486 makes acetate and butyrate from various substrates and is found in the human intestine. The proteome of choline -grown Eubacterium limosum was obtained in order to identify enzymes required for growth on choline, in particular to identify components that are unique to g...
ORGANISM(S): Eubacterium limosum Bacteria 
2025-06-16 | PXD033467 | Pride
Choline demethylation pathway Human gut isolate Acetogenic bacteria 
TranscriptomicsMERVL/Zscan4 network activation results in transient genome-wide DNA demethylation of mESCs
Several previous studies have noted a rare sub-population of murine Embryonic Stem Cells (mESCs) which seem to express genes otherwise specific to the 2-cell stage of embryonic development. Here we sorted single cells from a MERVL/Zscan4 reporter line to investigate the continuum of expression as ce...
ORGANISM(S): Mus musculus 
2016-09-30 | E-MTAB-5058 | biostudies-arrayexpress
UnknownMtcB, a member of the MttB superfamily from the human gut acetogen Eubacterium limosum, is a cobalamin-dependent carnitine demethylase.
Not available
S-EPMC7443480 | biostudies-literature
GenomicsTet2-mediated DNA demethylation controls T cell cytokine expression [seq]
The conversion of 5-methylcytosine (5mC) into 5-Hydroxymethylcytosine (5hmC) by ten-eleven translocation (Tet) family has recently been identified as a key process for active DNA demethylation, whose effects in the immune response is currently unknown. Examination of both 5mC and 5hmC modifications ...
ORGANISM(S): Mus musculus 
2015-04-12 | E-GEOD-49139 | biostudies-arrayexpress
TranscriptomicsThe mental retardation gene PHF8 mediates histone H4K20/H3K9 demethylation and regulates zebrafish brain apoptosis and craniofacial development: expression analysis
PHF8 (PHD Finger 8) mutations have been found in patients with X-linked mental retardation (XLMR) and craniofacial deformities. Here we identify PHF8 as the first enzyme that mediates demethylation of mono-methylated histone H4 lysine (K) 20 (H4K20me1), with additional activities towards H3K9me2/1 a...
ORGANISM(S): Homo sapiens 
2010-07-14 | E-GEOD-21555 | biostudies-arrayexpress
ProteomicsProteome of gamma-butyrobetaine-grown Eubacterium limosum ATCC 8486
Eubacterium limosum ATCC 8486 makes acetate and butyrate from various substrates and is found in the human intestine. The proteome of gamma-butyrobetaine -grown Eubacterium limosum was obtained in order to identify enzymes required for growth on gamma-butyrobetaine, in particular to identify compone...
ORGANISM(S): Eubacterium limosum Bacteria 
2021-11-04 | PXD020152 | Pride
Eubacterium limosum Gut microbiome Butyrobetaine Acetogen 
TranscriptomicsALKBH5 is a New Mammalian RNA Demethylase
N6-methyladenosine (m6A) is the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Here we report ALKBH5 as a new mammalian demethylase that oxidatively removes the m6A modification in mRNA in vitro and inside cells. This demethylation activity of ALKBH5 significantly...
ORGANISM(S): Mus musculus 
2013-02-15 | E-GEOD-40132 | biostudies-arrayexpress
GenomicsGenomic DNA of tumor tissues, adjacent normal tissues, and peripheral blood were extracted using QIAamp DNA mini Kit (QIAGEN, cat. #51306)
Although genomic instability, epigenetic abnormality, and gene expression dysregulation are hallmarks of colorectal cancer, these features have not been simultaneously analyzed at single cell resolution. Using optimized single cell multiomics sequencing together with multiregional sampling of the pr...
EGAS00001003242 | EGA
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