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MetabolomicsHuaban Tongmai Decoction ameliorates carotid artery atherosclerosis by inhibiting ferroptosis via the p53-Parkin mitophagy axis

Background: Carotid artery atherosclerosis (CAS), has exhibited an increasing incidence in recent years. Although Huaban Tongmai decoction (HBTMD) shows considerable therapeutic potential against CAS, the specific molecular mechanisms of its action remain incompletely defined.

Purpose: This...

2026-02-15 | MTBLS13908 | MetaboLights
MetabolomicsMetabolomic determinants of carotid atherosclerosis plaque stability
Our objective is to identify the metabolites associated with stability of carotid atheromatous plaques compared to vulnerable plaques, through a metabolomic approach. Eighty consecutive patients with carotid artery stenosis (CAS) who underwent carotid endarterectomy (CEA) according to current guidel...
2025-06-06 | MTBLS12303 | MetaboLights
TranscriptomicsTranscription profiling of rat carotid artery following arteriotomy
Effect of injuring carotid on trascription. Time comparison of rat carotid responses to injury with control.
ORGANISM(S): Rattus norvegicus 
2008-06-10 | E-MEXP-1278 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of stroke-susceptible and asymptomatic human carotid plaques
A microarray analysis of advanced human atherosclerotic carotid artery plaques (equal or over 70% stenosis, NASCET criteria) from radiologically confirmed ipsilateral stroke patients (stroke-susceptible plaques, n=12) compared with carotid plaques collected from clinically asymptomatic patients with...
ORGANISM(S): Homo sapiens 
2011-12-30 | E-MEXP-2257 | biostudies-arrayexpress
TranscriptomicsChanges in miR expression profile carotid plaques induced by acutely induced flow disturbances in apoe-/- mice on a high fat diet.
Atherosclerosis is causally related to disturbed flow through low and oscillatory shear stress. In order to study the miR expression profile in atherosclerotic plaques induced by disturbed flow, partial ligation of the carotid artery was performed. This procedure results acutely in severly reduced b...
ORGANISM(S): Mus musculus 
2012-12-26 | E-GEOD-26555 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of peripheral blood from patients with carotid artery stenosis
Identification of novel pathophysiological mechanisms of carotid artery disease at systemic level by studying the gene expression profile of peripheral blood of affected patients with respect to control subjects.
ORGANISM(S): Homo sapiens 
2009-06-30 | E-MEXP-2113 | biostudies-arrayexpress
TranscriptomicsThe Stockholm Atherosclerosis Gene Expression (STAGE) study: Global Gene Expression data from coronary and carotid artery disease patients
Tissue samples have been isolated during corornary artery by-pass grafting (CABG)surgery from the atheroscelrotic arterial wall (AAW, aortic root puncture for proxmal ligation of by-pass vessel), non-atherosclertoci arterial wall (NAAW, distal part of mammary artery used a graft for LAD), liver, sk...
ORGANISM(S): Homo sapiens 
2012-08-21 | E-GEOD-40231 | biostudies-arrayexpress
TranscriptomicsIdentification of novel mechanosensitive genes differentially regulated at 48 h timepoint in vivo using mouse carotid artery endothelium exposed to disturbed blood flow
Recently, we showed that disturbed flow caused by a partial ligation ofmouse carotid artery rapidly induces atherosclerosis. Analysis of mechanosenstive microRNA in the mouse carotid endothelium. In this study, we examined the microRNAs that respond differentially to blood flow pattern in the mouse ...
ORGANISM(S): Mus musculus 
2014-01-13 | E-GEOD-52243 | biostudies-arrayexpress
TranscriptomicsDeletion of hyaluronan synthase 3 inhibits neointimal hyperplasia
Affymetrix Mouse Gene 2.0 ST Gene Expression Microarrays were used to analyze differentially expressed genes after carotid artery ligation. The aim of this experiment was to detect genes regulated in Has3 deficient as compared to wildtype controls that might be involved in neointimal hyperplasia. Ne...
ORGANISM(S): Mus musculus 
2015-11-24 | E-GEOD-70410 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of asymptomatic and symptomatic atherosclerotic plaques from the same patient
We compared gene expression profiles between asymptomatic and symptomatic atherosclerotic plaques from the same patient. This was accomplished by analyzing carotid plaques from four patients with bilateral high-grade carotid artery stenoses one being symptomatic (TIA or stroke) and the other asympto...
ORGANISM(S): Homo sapiens 
2006-02-10 | E-MEXP-268 | biostudies-arrayexpress
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