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ProteomicsEffects of the chlorophyll derivative 132-hydroxypheophytine a on zebrafish metabolomics
Zebrafish larvae were exposed from 3 DPF to 5 DPF to the chlorophyll derivative 13-2-hydroxypheophytine a. Metabolites were extracted with some modification of the protocol published by Lin et al 2019 (10.1016/j.bbrc.2019.04.003.). 3 experimental groups: DMSO 0.1% (solvent control) and hpa at 7.5 ug...
ORGANISM(S): Danio Rerio (ncbitaxon:7955) 
2023-06-16 | MSV000092187 | MassIVE
MetabolomicsGNPS - Effects of the chlorophyll derivative 132-hydroxypheophytine a on zebrafish metabolomics
Zebrafish larvae were exposed from 3 DPF to 5 DPF to the chlorophyll derivative 13-2-hydroxypheophytine a. Metabolites were extracted with some modification of the protocol published by Lin et al 2019 (10.1016/j.bbrc.2019.04.003.). 3 experimental groups: DMSO 0.1% (solvent control) and hpa at 7.5 ug...
ORGANISM(S): Danio Rerio (ncbitaxon:7955) 
2023-06-16 | MSV000092187 | GNPS
ProteomicsDeciphering mechanism of actions of novel compounds by bioactive thermal proteome profiling
Exploring the therapeutic effects of bioactive compounds has been traditionally approaching by phenotypic screenings followed by functional validation by in vitro assays. The thermal proteome profiling (TPP) has been successfully applied to study drug targets and off-target. We applied a modified pr...
ORGANISM(S): Homo sapiens (Human) 
2019-06-28 | PXD013227 | Pride
Thermal proteome profiling  mechanism of actions  bioactive compound  label-free quantitative proteomics  marine biodiscovery 
ProteomicsProteome Integral Solubility Alteration assay in zebrafish embryo for exploring exposure to bioactive compounds including pollutants and chemicals mixtures
The One Health initiative connects human and animal health with their shared environment. The development of novel methodology to unbiased identification of mechanisms of action of chemicals and chemicals mixtures would address one of today´s challenges of environmental and human toxicology. Zebrafi...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2022-02-28 | PXD021670 | Pride
Thermal proteome profiling Bioactive compound Pollutants Drug target Zebrafish embryo Biodiscovery Novel drug Proteome integral solubility alteration assay Chemical mixtures 
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